BMJ: Dietary addition of n-3 and n-6 ​​fatty acids can relieve migraine headaches in adults

Although the treatment of migraine has improved in the past decade, many patients continue to suffer severe pain and disability despite taking multiple medications
.

Like many multifactorial chronic diseases, the incomplete understanding of the underlying biological mechanisms limits the development of effective prevention and treatment methods

Although the treatment of migraine has improved in the past decade, many patients continue to suffer severe pain and disability despite taking multiple medications

Christopher E Ramsden et al.

Established a 16-week ambulatory academic medical center in the United States
.

182 participants (88% were women, with an average age of 38) suffered from migraine 5-20 days a month (67% met the criteria for chronic migraine)

Established a 16-week ambulatory academic medical center in the United States

Intervention measures: Three diets designed with eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and linoleic acid as control variables: H3 diets (n=61) increase EPA+DHA To 1.

The primary endpoint (week 16) is the blood analgesic agent 17-hydroxydocosahexaenoic acid (17-HDHA) and the headache impact test (HIT-6), which is a six-item assessment of the impact of headache on quality of life Questionnaire

The effect of diet on precursor fatty acids

The effect of diet on precursor fatty acids

In the intention-to-treat analysis (n=182) , the circulating 17-HDHA (log ng/ml) increased in the H3-L6 and H3 diets compared with the control diet (baseline adjusted mean difference 0.
6, 95% confidence interval, respectively) They are 0.
2～0.
9, 0.
7, 0.
4～1.
1)
.

The improvement in HIT-6 scores observed in the H3-L6 and H3 groups was not statistically significant (-1.

In the intention-to-treat analysis (n=182) , the circulating 17-HDHA (log ng/ml) increased in the H3-L6 and H3 diets compared with the control diet (baseline adjusted mean difference 0.
6, 95% confidence interval, respectively) They are 0.
2～0.
9, 0.

The daily headache time is related to precursor fatty acids and oxidized lipids

Compared with the control diet, the H3-L6 and H3 diets reduced the total number of headache hours per day (-1.

7, -2.
5 to -0.
9 and -1.
3, -2.
1 to -0.
5, respectively), and reduced the number of moderate to severe headache hours per day (Respectively -0.

Compared with the control diet, the H3-L6 and H3 diets reduced the total number of headache hours per day (-1.

In summary, the study tested two positive dietary interventions aimed at the known biochemical mechanisms that regulate nociceptive sensations

Original source

Dietary alteration of n-3 and n-6 ​​fatty acids for headache reduction in adults with migraine: randomized controlled trial.
BMJ 2021; 374 doi: https://doi.
org/10.
1136/bmj.
n1448 

https://doi.
org/10.
1136/bmj.
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