BMC Medicine: The 3.5 million people queue study showed that BMI and waist circumference were associated with multiple cancer risks

The global prevalence of obesity has nearly tripled in the past 30 years, reaching 650 million in 2016 among adults.
body mass index (BMI), the most common indicator of obesity in general, has been shown to be associated with at least 12 types of cancer.
previous large-scale queue studies have shown that BMI is associated with more cancer types, and that some of these associations may be nonlinear.
, however, existing studies do not adequately take into account potential confuse factors, rely on self-reported weight and height, and many studies do not have results that are layered by smoking status.
, it remains to be seen whether BMI, the only indicator of obesity, fully reflects the complex relationship between obesity and cancer risk.
central obesity, usually assessed with waist circumference (WC), has been identified as increasing the risk of several types of cancer and better distinguishing the risk of obesity-related colon and post-menoptostrual breast cancer.
, however, only a few studies systematically compared the effects of BMI and WC on specific cancers in multiple locations, and none studied cancer types with lower rates.
As a result, Martina Recalde et al., using a forward-looking queue based on electronic health records in Catalonia, Spain, included 3,658,417 adults aged ≥18 years of age and without cancer between 2006 and 2017, investigating the association between BMI and 26 cancer risks, taking into account nonlinear relationships.
then compared general (BMI) and central (WC) obesity with 26 cancer risks.
showed that 202,837 participants were diagnosed with cancer after a medium follow-up time of 8.3 years. A higher BMI of
was positively associated with the risk of nine types of cancer (uterine coronary artery, kidney, gallbladder, thyroid gland, colorectal, post-masmosis, multiple myeloma, leukemia, non-Hodgkin's lymphoma) and positively associated with three other cancers in non-smokers (head, neck, brain and central nervous system, Hodgkin's lymphoma).
risk ratios (HRs) (5kg/m2 per increase) ranged from 1.04 (99% CI 1.01 to 1.08) for non-Hodgkin's lymphoma to 1.49 (1.45 to 1.53) for uterine cancer.
Although BMI was negatively associated with five types of cancer in the linear analysis of the population, it was found that BMI was associated with U-type prostate cancer, L-type correlation with head and neck cancer, esophageal cancer, throat and tracheal cancer, bronchal cancer and lung cancer, indicating that low BMI was the result of heavy smoking.
27,837 of the 291,305 participants measured by WC were diagnosed with cancer.
the BMI and WC of all cancers overlapped with the 99% confidence interval of the HR point estimates for all cancers (one additional standard deviation), suggesting that BMI and WC are comparable to cancer risk.
: In this large southern European study, higher BMI was associated with an increased risk of 12 types of cancer, and BMI and WC showed a comparable relationship with cancer risk.
the findings suggest that in public health strategies to prevent cancer, the focus should be on reducing obesity, and that using BMI to assess obesity-related cancer risks may be sufficient.
Recalde, M., Davila-Batista, V., Díaz, Y. et al. Body mass index and waist circumference in relation to the risk of 26 types of cancer: a prospective cohort study of 3.5 million adults in Spain. BMC Med 19, 10 (2021). MedSci Original Source: MedSci Original Copyright Notice: All text, images and audio and video materials on this website that indicate "Source: Mets Medicine" or "Source: MedSci Original" are owned by Mets Medicine and are not authorized to be reproduced by any media, website or individual, and are authorized to be reproduced with the words "Source: Mets Medicine".
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