echemi logo
Product
  • Product
  • Supplier
  • Inquiry
    Home > Active Ingredient News > Antitumor Therapy > BMC Cancer: Efficacy and safety of cisplatin plus etoposide (EP) vs carboplatin plus etoposide (EC) in the treatment of extensive-stage SCLC

    BMC Cancer: Efficacy and safety of cisplatin plus etoposide (EP) vs carboplatin plus etoposide (EC) in the treatment of extensive-stage SCLC

    • Last Update: 2021-12-24
    • Source: Internet
    • Author: User
    Search more information of high quality chemicals, good prices and reliable suppliers, visit www.echemi.com

    Small cell lung cancer (SCLC) is a highly aggressive type of lung cancer, accounting for approximately 15% of all newly diagnosed lung cancer cases


    Small cell lung cancer (SCLC) is a highly aggressive type of lung cancer, accounting for approximately 15% of all newly diagnosed lung cancer cases


    Among the 1305 patients included, most were male (n = 928, 68.


    Among the 1305 patients included, most were male (n = 928, 68.


    After excluding 4 patients lacking survival data, 1301 patients were included for survival analysis



    PFS and OS

    Multivariate analysis showed that female patients (HR = 0.


    Multivariate analysis showed that female patients (HR = 0.


    After adjusting for age, gender, body mass index, ECOG PS and other factors, the EP program is for overweight and obese patients (BMI ≥25 kg/m 2 ) PFS (hazard ratio [HR] = 0.




    In the safety analysis, patients who received EC treatment experienced grade 3 AEs (n = 599, 74.




    In summary, studies have shown that there is no significant difference between EC and EP regimens in the first-line treatment of patients with extensive-stage SCLC


    Original source:

    Original source:

    Jiang S, Huang L, Zhen H, Jin P, Wang J, Hu Z.


    Jiang S, Huang L, Zhen H, Jin P, Wang J, Hu Z.
    Carboplatin versus cisplatin in combination with etoposide in the first-line treatment of small cell lung cancer: a pooled analysis.
    BMC Cancer.
    2021 Dec 7;21( 1):1308.
    doi: 10.
    1186/s12885-021-09034-6.
    PMID: 34876060; PMCID: PMC8650295.


    Leave a message here
    This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only. This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed description of the concern or complaint, to service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content will be removed immediately.

    Contact Us

    The source of this page with content of products and services is from Internet, which doesn't represent ECHEMI's opinion. If you have any queries, please write to service@echemi.com. It will be replied within 5 days.

    Moreover, if you find any instances of plagiarism from the page, please send email to service@echemi.com with relevant evidence.