Blood: Tumor-related myelin cells provide important support for T-ALL.

Al !----though there are mutations in cancer-causing and anti-cancer genes that promote cancer growth, acute T-lemphoblastic leukemia (T-ALL) cells still require exoplanets or signals to survive in vitro cultureLyu and others have previously found myelin cells from thymus tumor microenvironments (TME), especially dendritic cells (DCs), to support the survival and proliferation of T-ALL cells in in vitro protomousere micetherefore, it assumes that tumor-related myelin cells can also support T-ALL in the bodyconsistent with this possibility, depletion of myelin cells in the body in two different T-ALL mouse models significantly reduces the leukaemia burden in multiple organs and prolongs the survival of micethe effect of themyelin chamber on T-ALL growth does not depend on the inhibition of antitumor T-cell response, myelin cells are signals that provide direct support for T-ALL cellsthe experiments of transcriptional spectrum analysis, functional assays and acute myelin depletion in the body, it was determined that IGF1R activation was a key component of myelin-mediated T-ALL growth and survivalthe researchers also identified several myelin subgroups that directly support the viability of T-ALL cellsconsistent with the results in the mouse model, myelin cells derived from peripheral blood mononuclear cells activate IGF1R and directly support in vitro survival of T-ALL cells in primary patientsin addition, the gene markers of macrophages in published clinical samples were associated with adverse prognosis in pediatric T-ALL patientsin general, these data suggest that tumor-related myelin cells provide important signals for T-ALL growth in multiple organs, suggesting that tumor-related myelin cells and associated signals may be used as potential therapeutic targets.