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Blood: Tigrelor prophylaxis does not reduce vascular occlusive crisis in children with sickle cell disease

 Last Update: 2022-10-12
 Source: Internet
 Author: User

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Sickle cell disease (SCD) is an autosomal recessive, hematologic disorder that β globin mutations that cause hemoglobin S (HbS) to polymerize

The Phase 3 HESTIA3 study aimed to evaluate the efficacy and safety

Patients with SCD aged 2-17 years are randomly (1:1) divided into two groups and receive either tigrelor or a matched placebo based on body weight

Overall, a total of 193 patients from 16 countries were randomly assigned to the tegrelo group (101) or placebo group (92

The median platelet suppression rate at 6 months of tegrelor intervention was 34.

In summary, the prevention of the use of ticagrelol did not reduce the occurrence

Original Source:

Matthew M.

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