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This article is original by Translational Medicine Network.
Please indicate the source for reprinting.
Author: Liz Zee Guide: A new study led by researchers at the University of California, Davis, shows that blocking IL-6 and TNF cytokines is a way to prevent life-threatening transplants Graft-versus-host-disease (GVHD) provides a more effective method.
Graft-versus-host-disease (GVHD) occurs in patients with allogeneic hematopoietic stem cell transplantation (allogeneic hematopoietic stem cell transplantation, allo-HSCT).
) After an inflammatory disease
.
This study was published yesterday (December 16) in "Blood", titled "Increased efficacy of dual proinflammatory cytokine blockade on acute GVHD while maintaining GVT effects"
.
https://doi.
org/10.
1182/blood.
2021011216 Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) is a method for the treatment of blood diseases and cancer.
It requires the injection of donor bone marrow stem cells into patients undergoing intensive chemotherapy and radiation therapy In vivo
.
Immune cells donated in the transplanted tissue (graft) have an immune response to the patient's tumor cells, resulting in a graft anti-tumor (GVT) effect
.
However, these cells may also attack the patient's healthy tissues, possibly causing fatal graft-versus-host disease (GVHD)
.
What is graft-versus-host disease? Graft-versus-host disease (GVHD) is an important cause of allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients
.
This happens when the donor immune cells in the transplant attack multiple organs and induce a "cytokine storm" (excessive pro-inflammatory response caused by cytokines)
.
Acute graft-versus-host disease (GVHD) occurs early after transplantation
.
Chronic graft-versus-host disease (GVHD) appears late, is accompanied by delayed inflammation, and may lead to tissue fibrosis
.
"Graft-versus-host disease (GVHD) is still the main obstacle to cancer patients, stem cell transplant success
.
"
Distinguished professor, senior author of the study, deputy director of the Institute of Dermatology and within departments of William Murphy he said
.
Blocking from single to two cytokines TNF and IL-6 are two cytokines that play a key role in many health conditions, including autoimmunity and excessive immune responses to viruses, such as SARS-CoV-2 (causing COVID-19 virus)
.
The current treatment is mainly to block one of the cytokines to control the cytokine storm
.
Targeting a single cytokine has been successfully used in some cases, such as blocking TNF for the treatment of autoimmune diseases, blocking IL6 for the treatment of cytokine release syndrome after CAR-T cell immunotherapy and COVID-19 infection
.
However, there is currently no assessment of blocking these two cytokines at the same time
.
"In terms of preventing graft-versus-host disease (GVHD), only a single cytokine blockade of IL6 or TNF was evaluated, and the clinical results were not satisfactory
.
Therefore, we believe that it is necessary to block these two cytokines at the same time to obtain greater efficacy
.
"Murphy said
.
Compared with blocking a single cytokine, blocking two cytokines has less cell death in the intestines and has a better effect.
Severe obesity mouse models were treated with a combined blockade of TNF and IL-6
.
Recent studies by Murphy and his team have shown that due to the further enhancement of the cytokine storm, host diseases (such as obesity) can make the acute graft resistant Host disease (GVHD) has worsened
.
In COVID-19 cases and other disease cases, the role of obesity in the outbreak of cytokine storms has also been observed
.
The study found that blocking these two cytokines can better alleviate acute The severity of graft-versus-host disease (GVHD) and the reduction of mortality
.
It is
important that the combined blocking therapy does not affect the effect of graft-versus-host disease ( GVT)
.
"Many treatments for graft-versus-host disease (GVHD) Methods will suppress the body's immunity, which may inhibit the beneficial graft anti-tumor (GVT) effect
.
Therefore, it is important to determine whether blocking these two cytokines will affect the anti-tumor (GVT) effect of the graft
.
Fortunately, after combined blocking therapy, the anti-tumor effect still exists after transplantation
.
"The study's first author and postdoctoral researcher Lam T.
Khuat at the University of California, Davis said
.
This study may help find better treatments for pro-inflammatory diseases (such as COVID-19)
.
Currently, only IL-6 blockers are used to prevent the cytokine storm caused by the body's excessive immune response to the coronavirus
.
"The improved therapeutic effect of combined blockade suggests that this method of treating diseases caused by inflammation may have greater benefits in other clinical settings
.
" Murphy said
.
Reference materials: https://medicalxpress.
com/news/2021-12-potential-treatment-graft-versus-host-disease-inflammatory-disorders.
html Note: This article aims to introduce medical research progress and cannot be used as a reference for treatment options
.
If you need health guidance, please go to a regular hospital for treatment
.
Recommendation·Activity [Live Preview] Application Progress and Practice Discussion of NGS Technology in Cancer Clinical Research [Online Seminar] 2021 Congenica Genome Analysis Platform Clinical Practice Seminar, sharing themes with big names, and giving away multiple gifts! Popular·Article Cancer Research [Cell] Chinese scientists and their teams created barcodes to quickly decipher the "chat" gut microbes between cancer cells [BMJ Sub-Journal] Why are good foods suddenly intolerant? New research has identified a unique profile of intestinal bacteria that is highly sensitive to dietary therapy for irritable bowel syndrome, the new coronavirus [Nature sub-Journal] Human genetics perspective-how genetic mutations affect our immune cells, resulting in different severity of COVID-19 Virus [Nature Sub-Journal] Appropriate vitamin D supplementation can fight inflammation, including new coronary pneumonia! Cancer Research [Cell Sub-Journal] MIT researchers have discovered a secret way to fight tumors-wear tumor cell vests and kill tumor cells! Basic research [Nature Sub-Journal] is amazing! 3D images of mouse skulls help scientists create new bones! Basic research [ATS Sub-Journal] Breakthrough! To map the most comprehensive molecular roadmap of human lung proteins, scientists identified and measured 8,938 proteins!
Please indicate the source for reprinting.
Author: Liz Zee Guide: A new study led by researchers at the University of California, Davis, shows that blocking IL-6 and TNF cytokines is a way to prevent life-threatening transplants Graft-versus-host-disease (GVHD) provides a more effective method.
Graft-versus-host-disease (GVHD) occurs in patients with allogeneic hematopoietic stem cell transplantation (allogeneic hematopoietic stem cell transplantation, allo-HSCT).
) After an inflammatory disease
.
This study was published yesterday (December 16) in "Blood", titled "Increased efficacy of dual proinflammatory cytokine blockade on acute GVHD while maintaining GVT effects"
.
https://doi.
org/10.
1182/blood.
2021011216 Allogeneic Hematopoietic Stem Cell Transplantation (allo-HSCT) is a method for the treatment of blood diseases and cancer.
It requires the injection of donor bone marrow stem cells into patients undergoing intensive chemotherapy and radiation therapy In vivo
.
Immune cells donated in the transplanted tissue (graft) have an immune response to the patient's tumor cells, resulting in a graft anti-tumor (GVT) effect
.
However, these cells may also attack the patient's healthy tissues, possibly causing fatal graft-versus-host disease (GVHD)
.
What is graft-versus-host disease? Graft-versus-host disease (GVHD) is an important cause of allogeneic hematopoietic stem cell transplantation (allo-HSCT) patients
.
This happens when the donor immune cells in the transplant attack multiple organs and induce a "cytokine storm" (excessive pro-inflammatory response caused by cytokines)
.
Acute graft-versus-host disease (GVHD) occurs early after transplantation
.
Chronic graft-versus-host disease (GVHD) appears late, is accompanied by delayed inflammation, and may lead to tissue fibrosis
.
"Graft-versus-host disease (GVHD) is still the main obstacle to cancer patients, stem cell transplant success
.
"
Distinguished professor, senior author of the study, deputy director of the Institute of Dermatology and within departments of William Murphy he said
.
Blocking from single to two cytokines TNF and IL-6 are two cytokines that play a key role in many health conditions, including autoimmunity and excessive immune responses to viruses, such as SARS-CoV-2 (causing COVID-19 virus)
.
The current treatment is mainly to block one of the cytokines to control the cytokine storm
.
Targeting a single cytokine has been successfully used in some cases, such as blocking TNF for the treatment of autoimmune diseases, blocking IL6 for the treatment of cytokine release syndrome after CAR-T cell immunotherapy and COVID-19 infection
.
However, there is currently no assessment of blocking these two cytokines at the same time
.
"In terms of preventing graft-versus-host disease (GVHD), only a single cytokine blockade of IL6 or TNF was evaluated, and the clinical results were not satisfactory
.
Therefore, we believe that it is necessary to block these two cytokines at the same time to obtain greater efficacy
.
"Murphy said
.
Compared with blocking a single cytokine, blocking two cytokines has less cell death in the intestines and has a better effect.
Severe obesity mouse models were treated with a combined blockade of TNF and IL-6
.
Recent studies by Murphy and his team have shown that due to the further enhancement of the cytokine storm, host diseases (such as obesity) can make the acute graft resistant Host disease (GVHD) has worsened
.
In COVID-19 cases and other disease cases, the role of obesity in the outbreak of cytokine storms has also been observed
.
The study found that blocking these two cytokines can better alleviate acute The severity of graft-versus-host disease (GVHD) and the reduction of mortality
.
It is
important that the combined blocking therapy does not affect the effect of graft-versus-host disease ( GVT)
.
"Many treatments for graft-versus-host disease (GVHD) Methods will suppress the body's immunity, which may inhibit the beneficial graft anti-tumor (GVT) effect
.
Therefore, it is important to determine whether blocking these two cytokines will affect the anti-tumor (GVT) effect of the graft
.
Fortunately, after combined blocking therapy, the anti-tumor effect still exists after transplantation
.
"The study's first author and postdoctoral researcher Lam T.
Khuat at the University of California, Davis said
.
This study may help find better treatments for pro-inflammatory diseases (such as COVID-19)
.
Currently, only IL-6 blockers are used to prevent the cytokine storm caused by the body's excessive immune response to the coronavirus
.
"The improved therapeutic effect of combined blockade suggests that this method of treating diseases caused by inflammation may have greater benefits in other clinical settings
.
" Murphy said
.
Reference materials: https://medicalxpress.
com/news/2021-12-potential-treatment-graft-versus-host-disease-inflammatory-disorders.
html Note: This article aims to introduce medical research progress and cannot be used as a reference for treatment options
.
If you need health guidance, please go to a regular hospital for treatment
.
Recommendation·Activity [Live Preview] Application Progress and Practice Discussion of NGS Technology in Cancer Clinical Research [Online Seminar] 2021 Congenica Genome Analysis Platform Clinical Practice Seminar, sharing themes with big names, and giving away multiple gifts! Popular·Article Cancer Research [Cell] Chinese scientists and their teams created barcodes to quickly decipher the "chat" gut microbes between cancer cells [BMJ Sub-Journal] Why are good foods suddenly intolerant? New research has identified a unique profile of intestinal bacteria that is highly sensitive to dietary therapy for irritable bowel syndrome, the new coronavirus [Nature sub-Journal] Human genetics perspective-how genetic mutations affect our immune cells, resulting in different severity of COVID-19 Virus [Nature Sub-Journal] Appropriate vitamin D supplementation can fight inflammation, including new coronary pneumonia! Cancer Research [Cell Sub-Journal] MIT researchers have discovered a secret way to fight tumors-wear tumor cell vests and kill tumor cells! Basic research [Nature Sub-Journal] is amazing! 3D images of mouse skulls help scientists create new bones! Basic research [ATS Sub-Journal] Breakthrough! To map the most comprehensive molecular roadmap of human lung proteins, scientists identified and measured 8,938 proteins!
