Blood: LUBAC promotes lymphoma formation by blocking DNA damage-induced cell death

Linear Ubiquital chain assembly complex (LUBAC) is a key regulatory factor for the NF-kB signaling pathwayLUBAC's catalytic sub-nucleotide polymorphism was concentrated in activated B-cell-like diffuse large B-cell lymphoma (ABC-DLBCL) patients, and HOIP, which had LUBAC activity similar to, was expressed higher in THE ABC-DLBCL sampleto clarify the exact role of LUBAC in lymphatic development, the researchers created a mouse model of HOIP expression enhancement in B cellsinteresting is that ENHANCEd HOIP expression promotes the production of DLBCL-like B-cell lymphocytes driven by myD88 activation mutationDeveloped lymphoma cells share partial somatic cell gene mutations with human DLBCLs, and the frequency of typical AID mutation patterns increasesin vitro analysis offound that HOIP overexpression protects B cells from DNA damage through NF-kB activation, and analysis of human DLBCL database found that HOIP expression is positively correlated with gene labels and NF-kB signal expressions that express apoptosis signal regulationthe results show that HOIP promotes lymphatic development by preventing cell death and enhancing NF-kB signals, leading to the accumulation of AID-mediated mutationsin addition toa natural compound has been found in mouse transplant models that specifically inhibitLUBAC, thereby inhibiting tumor growthin general,, this study shows that LUBAC plays a key role in the occurrence of B-cell lymphoma by protecting DNA damage-induced cell death and is a potential therapeutic target for B-cell lymphoma