Blood: Isolated pulmonary embolism, don't go the usual way!

Isolated pulmonary embolism (PE) patients with deep vein thrombosis (DVT)-related pulmonary embolism patients have significantly different clinical characteristics, accompanied by more lung disease and atherosclerosis.
findings suggest that there may be unique molecular pathophysiological characteristics and different participatory signaling pathogenesis in isolated pulmonary embolisms.
to test the hypothesis, the researchers analyzed data from 532 subjects in a multi-center prospective cohort study called the Genotype and Molecular Esotype (GMP-VTE) Project for Venous Thrombosis.
the 532 subjects, including 96 patients with isolated pulmonary embolism, 276 patients with DVE-related pulmonary embolism, and 160 patients with isolated DVT.
used targeted high-volume proteomics, machine learning, and bio-information methods to compare plasma proteomics during acute periods in patients with different diseases.
comparative analysis, it was found that there was the same molecular process between different peculiar pulmonary embolisms, and protein markers specific to isolated pulmonary embolisms were also identified.
common processes include increased inflammation, stress response to oxidation, and loss of surfactants in the lungs.
protein markers specific to isolated pulmonary embolism consist of five proteins: interferon-γ (IFNG), glial cytoplasmic neurotrophic growth factor (GDNF), polypeptide N-acetyl semi-lactamine-based transferase 3 (GALNT3), type 2 peptide-based arginine deserinease (PADI2) and leukocentin-15 subject α -15R alpha.
these proteins were orthososmissically validated using cis pQTL.
Externally validated the above proteomics results in a separate population-based queue (n-5,778) and found that these proteins can predict the likelihood of primary isolated pulmonary embolism in individuals without a VTE history (mean time: 2.9 years, tempromation range: 1.6-4.2 years), suggesting that these proteins may be involved in the early onset of isolated pulmonary embolism.
in short, the study identified similar and different molecular pathology between different VTE estypes.
, in particular, in the acute pathophysiological process of isolated PE, atypical pathogenesies that mediate VTE occur are more common in patients with combined respiratory tract and atherosclerosis diseases.