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Blood: EMT regulator SNAI1 promotes AML progress through interaction with LSD1

 Last Update: 2020-05-29
 Source: Internet
 Author: User

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In recent years, the regulatory factors of epithelial-interstitial transformation (EMT) have become new members of the field of leukemia biologyHowever, the mechanism by which EMT regulatory factors are involved in the onset of leukemia is not completely clearin this study
, Carmichael et alfound that a key regulatory factor of EMT, SNAI1, is a pathologically related event in human acute myeloid leukemia (AML), which can lead to impaired differentiation, self-renewal, and proliferation of immature myelin cellsin addition, the researchers also demonstrated in mice that allogeneic expression in hematopoietic cells can lead to the development of acute myeloid leukemiaThis action is mediated by interaction with histone demethylase KDM1A/LSD1this study reveals the new role of SNAI1 in the development of leukemia and identifies new mechanisms for the destruction of LSD1 in cancerThis is particularly important in view of the current interest in LSD1 inhibitors in the treatment of many different malignancies, including AML

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