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Blood: Darafinil plus trametinib for relapsed/refractory BRAF V600E mutant hair cell leukemia

 Last Update: 2022-10-12
 Source: Internet
 Author: User

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Hairy cell leukemia (HCL) is a rare inert B-cell proliferative malignant hematopathy that is commonly associated

The study was an open-label, Phase 2 clinical trial that enrolled patients with positive HCL of BRAF V600E mutations who did not respond to first-line therapy with purine analogues or who relapsed after previous treatment with

Patients with

The most common treatment-related adverse effects were fever (58.

In summary, dalafinil plus trametinib demonstrated a durable response and controlled safety in patients with HCL positive for relapsed/refractory BRAF V600E mutations, consistent with what had previously been observed in patients with other indications, and could be considered as a treatment option

Original Source:

Kreitman Robert J,Moreau Philippe,Ravandi Farhad et al.

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