Blood: CAR-modified memory-like NK cells significantly improve NK's therapeutic response to resistant lymphoma
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Last Update: 2020-07-16
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Source: Internet
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Author: User
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!---- NK cell is a promising immunotherapy for tumor cellscytokine-induced memory sample (ML) NK cells differentiate after being activated by IL-12, IL-15 and IL-18, exhibiting a strong anti-tumor response that safely induces complete remission in leukemia patientsHowever, many cancers are not yet fully identified by NK cellschimeric antigen receptors (CARs) have been used to enhance tumor-specific identification of effect lymphocyteshypothetical memory differentiation and CAR programming such asGang can lead to complementary improvements in NK cells' response to NK-resistance to cancerto verify this, the researchers modified peripheral blood ML NK cells to express anti-CD19 CAR (19-CAR-ML);in addition, 19-CAR-ML NK of the source of lymphoma showed better response to their own lymphoma19-CAR-ML NK cells can control lymphoma load in the body and improve the survival of the heterogeneous transplant modeltherefore, the CAR engineering of ML NK cells enhances the response to drug-resistant cancer, which is worthy of further study and may expand the identification of ML NK cells in various NK cells resistant tumors
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