Blood: Analysis of whole gene transcription of late skin T-cell lymphoma STAT-6 regulatory gene

Signal converters and transcriptional activation factor 6 (STAT-6) are key upstream regulatory factors for IL-13 and IL-4 signals, and are constituent lymphocytes in Sezary syndrome (SS) and granuloma (MF), the most common subtypes of skin T-cell lymphomainhibitSTAT-6 by combining genome-wide expression spectrum and drugs, the researchers found that several common pathways regulated by STAT-6 in MF/SS malignant lymphoma were associated with cell cycle progression regulation and genomic stability, as well as the production of Th2 cytokinesthrough in vitro skin implants from skin MF tumors, as well as Sezary cells from the blood of SS patients, the researchers confirmed that in MF/SS malignant lymphocytes, STAT-6 activation can desize the production of cytokines, inducing cell cycle blocking, which in turn inhibits tumor cell proliferation, but does not affect their survivalIn addition, the researchers found that STAT-6 promotes tumor-related macrophages in the tumor microenvironment of late MF by increasing the expression of genes associated with immunosuppression, chemokines, and tumor matrix reconstructiontherefore, the researchers found that STAT-6 was the main factor in the onset and progression of MF/SS, promoting the proliferation and invasion of malignant lymphocytes, while inducing the inhibition of anti-tumor immune responseIn summary, the results of this study provide new insights into the pathogenesis of MF/SS and provide new potential targets for its therapeutic interventions