Blood: About half of ITP patients may have hidden brain haemorrhage!

The management of symptoms of immunocytosis (ITP) and the prevention of life-threatening bleeding must be balanced against adverse reactions to existing treatments.
since current treatment guidelines based on plateboard counts are confused by different hemorrhagic dedicates, it is necessary to identify objective markers related to the severity of new diseases in order to improve treatment stratization.
, 49 ITP patients were included in this cross-sectional, prospective study, with a minimum plateboard record of less than 30 x 109/L.
researchers used susceptible weighted MRI (SWI) to detect cerebral microbleeding (CMB) as a sign of hidden bleeding.
use semi-automated methods to detect CMB and use multivariable Poisson regression analysis to associate it with clinical data.
detection rate of cerebral echo CMB was 43% (21/49); 11;10 to 14x109/L:2/9;
mucous membrane and skin bleeding score, number of previous treatments, age and gender were independent of CMB.
hidden cerebral microbleeding is common in moderate to severe ITP patients.
correlation between this and ITP duration may reflect CMB accumulation or more difficult to treat over time.
correlation, neither low plateboard counts nor bleeding scores can predict CMB.
therefore, SWI can provide an additional non-invasive biometric indicator of hemorrhagic dedication and may be used as an aid to therapeutic stratization.
longitudinal studies of children and adults have helped us better understand the natural processes, clinical and prognosmation implications of CMB.
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