Biophysical J: New Discovery in Cancer Treatment! Cancer cells actually inject substanceinto into other cells!

April 9, 2020 /
Biovalley BIOON / - Although most cancer cells are killed by chemotherapy, individual cells are sensitive differently, so some cancer cells often escape Therefore, the diversity of cancer cells is a cancer treatment problem previously, this diversity was thought to be largely due to genetic variations between cancer cells Now, however, researchers at the University of Sydney have discovered a new source of cancer cell diversity, which has profound implications for cancer treatment In 2012, a team of researchers led by Han Zoellner, a professor at the University of Sydney's School of Dentistry, published a paper saying that cancer cells exchange substances with normal cells called fibroblasts around them, but their mechanisms are still unclear picture source: Prof Han Zoellner Now Zoellner's team published their latest findings in the journal Biophyical Journal all cells are constantly detecting each other with tentacle-like cell projection As part of the way cells perceive their surroundings, these cells extend their tentacles to the surrounding cells, detect them, and then contract When cells project contraction, there is a brief increase in fluid pressure at the projection, forcing the cytoplasm (the gel-like liquid within the cell) back to the cell body Professor Zoellner, studying cells in time-lapse photography, noted that the exchange of matter between cancer cells and normal cells comes from shrink cell projection he reasoned that the instantaneous microfusion between the shrinking cell projection and any adjacent cell would allow the cytoplasm projected by the cell to be injected into the adjacent cell, rather than back to the fibroblasts Zoellner and his team, who work at the School of Medicine and Health in Sydney and are on vacation at the Sloan Kettering Cancer Center in New York, tested the idea through mathematical modeling, cell experiments and computer simulations The result was the discovery of a previously unknown biological mechanism, now known as "cell projection pumping." cancer cells become more aggressive after cell projection
Another study published by Professor Zoellner's team in collaboration with Memorial Sloan-Kettering Cancer Center also highlights the importance of cell projection pumps They found that after cell projection, cancer cells became more diverse in size and shape and moved faster Importantly, preliminary results show edified further effects of chemotherapy resistance continues, Zoellner said: "It's a whole new anti-cancer goal Now that we know it's happening, we can consider trying to stop it and try ingres stoain for better results It's been a tough project for 19 years and it's hard to raise money, but I'm happy to have such great colleagues and I'm proud of my team's persistence (biovalleybioon.com) 1 Dicovery that cell cell each open new line on cancer
2 Hanelner et al, Potential Hydrodynamic Cytotonottine Tranfer Mammal Serian Cell: Cellphy-Projection Pumping , Bioic Journal (2020) DOI: 10.1016/j.bpj.2020.01.025