Biomed Pharmacother: Heptafluoroetheration protects mitochondrial function and reduces myocardial ischemia/reperfusion damage

!---- background and purpose anaesthetic can reduce myocardial ischemia reperfusion (I/R) damage, while heptafluoroetherine and propofol can produce cardiomyocardial protection through different molecular mechanismsstudy is intended to test the hypothesis that, unlike propylene phenol, heptafluoroethee acts as an anti-I/R damage cardiomyopathy through mitochondrial mechanismsfrench male New Zealand great white rabbit (n s 42), coronary artery ligation 30min, and then filled with 3hAftersodium penbarbital induced anesthesia, inhalation of heptafluoroetherine or intravenous propofol is maintained for general anesthesiause TTC staining to determine the area of myocardial infarctionseparatethed the mitochondria of the heart muscle and the mitochondria were measured with Clark electrodesthe activity of the mitochondrial respiratory chain complex (I-IV) is analyzed with specificityexperimental data is expressed as an average of standard deviationresultsignificantd in the area of myocardial infarction compared to propofol, heptafluoretherine anesthesia significantly reduced the area of myocardial infarction (p-0.0275 vspropofol group)significant reduction in mitochondrial respiratory control rate in the propofol anaesthetic group (p.01909 vspseudo-surgery group), respiratory chain complex I (p.0147 vspseudo-surgery group; p-lt;0.01 vs.7 fluoroether group) and complex IV (p-0.0181pseudosurgery group) were impairedand heptaflueee ether anaesthetic group and wireless granule dysfunctionin addition, the respiratory chain complex I of the heptafluoretheration group was significantly higher during I/R injury concluding theory compared with propofol anesthesia, heptafluoroethee can retain mitochondria respiration and have a protective effect on I/R damage