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Source: Guanlan Pharmaceutical
Recently, BeiGene announced that a phase 1 clinical trial of its in-development hematopoietic stem cell kinase 1 (HPK1) inhibitor BGB-15025 has completed its first patient administration.
HPK1 is a key negative feedback regulator of T cell receptor (TCR) signaling and is believed to play a key role in the anti-tumor immune response.
The press release shows that the first phase 1 clinical trial in humans launched this time aims to evaluate the safety, tolerability, and pharmacokinetics of BGB-15025 as a single agent or in combination with Bezan in patients with advanced solid tumors.
Note: The original text has been deleted
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