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A group of biological scientists from Durham University in the United Kingdom conducted a new study in collaboration with the University of Liverpool, Northumbria University and the New England Biological Laboratory, hoping to use the new characteristic defense system of bacteria to compare changes in the human genome
Undergraduates from Durham University are also conducting this research to prove the complex working mechanism of bacterial innate immunity
Bacteria have evolved a variety of defense systems to protect themselves from viruses.
The researchers demonstrated that the two defense systems work in complementary ways to protect bacteria from bacteriophages
A system protects bacteria from the influence of bacteriophages, which do not have any modification to their DNA
Some phages modify their DNA to avoid this first defense system
The researchers constructed extremely detailed three-dimensional images of BrxU to better understand how it protects the phage with modified DNA
BrxU has the potential to become another useful biotechnology tool because the same DNA modifications that BrxU recognizes appear throughout the human genome and are altered in cancer and neurodegenerative diseases
The senior author of the study, the Liszt Institute Prize winner of the Department of Biological Sciences at Durham University, and associate professor Dr.
This extra layer of information, the "epigenome," changes as we grow, and also changes in cases of cancer and neurodegenerative diseases
"If we can develop BrxU as a biotechnical tool for mapping this epigenome, it will change our understanding of the adaptive information that controls our growth and disease progression
The study’s lead author, Dr.
The 97 undergraduates who participated in this study were in the final years of their bachelor's or master's degrees in the Department of Biological Sciences at Durham University
As part of the Microbiology Symposium that aims to provide research-led teaching, their task is to isolate new bacteriophages for research
Bacteriophages were collected from the Weir River, University Pond and other waterways around Durham
DOI
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