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It is reported that AIM2 is a component of the innate immune cell inflammasome
.
Surprisingly, B cells express AIM2 , and higher AIM2 expression is observed in the B cells of lupus patients .
It is reported that AIM2 is a component of the innate immune cell inflammasome
This study from the team of Dr.
Qianjin Lu of the Second Xiangya Hospital of Central South University reported that the expression of AIM2 increased in memory B cells and germinal center (GC) B cells of human tonsils , and in the circulating memory B cells and plasma of lupus patients.
Increased expression in cells and skin
This study from the team of Dr.
Qianjin Lu of the Second Xiangya Hospital of Central South University reported that the expression of AIM2 increased in memory B cells and germinal center (GC) B cells of human tonsils , and in the circulating memory B cells and plasma of lupus patients.
Increased expression in cells and skin
in conclusion:
Conclusion: Conclusion:The study found that AIM2 is highly expressed in B cells of patients with lupus , and promotes B cell differentiation by regulating Bcl-6 - Blimp-1 , providing a new target for the treatment of systemic lupus erythematosus .
The study found that AIM2 is highly expressed in B cells of patients with lupus , and promotes B cell differentiation by regulating Bcl-6 - Blimp-1 , providing a new target for the treatment of systemic lupus erythematosus .
Source:
Source:Yang M, Long D, Hu L, Zhao Z, Li Q, Guo Y, He Z, Zhao M, Lu L, Li F, Long H, Wu H, Lu Q.
AIM2 deficiency in B cells ameliorates systemic lupus erythematosus by regulating Blimp-1-Bcl-6 axis-mediated B-cell differentiation.
Signal Transduct Target Ther.
Yang M, Long D, Hu L, Zhao Z, Li Q, Guo Y, He Z, Zhao M, Lu L, Li F, Long H, Wu H, Lu Q.
AIM2 deficiency in B cells ameliorates systemic lupus erythematosus by regulating Blimp-1-Bcl-6 axis-mediated B-cell differentiation.
Signal Transduct Target Ther.
2021 Sep 14;6(1):341.
doi: 10.
1038/s41392-021-00725-x.
PMID: 34521812.
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