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Autophagy is an evolutionarily conserved degradation process that helps eliminate unwanted proteins and damaged organelles, and provides necessary nutrients for cell survival, especially under various stress conditions.
Recently, researchers found that MCOLN1/TRPML1 is a pancreatic cancer , breast cancer ,Drug targets for carcinogenic autophagy in cancers such as gastric cancer , malignant melanoma and glioma.
Pancreatic cancer breast cancerStomach cancer
In recent studies, researchers have shown that by increasing the expression of the MCOLN1 channel or using the MCOLN1 agonist ML-SA5 or MK6-83 to activate MCOLN1, the fusion between autophagosomes and lysosomes can be disrupted to prevent cell autonomy.
MCOLN1 regulates autophagy by mediating zinc release from lysosomes MCOLN1 regulates autophagy by mediating zinc release from lysosomes.
Activation of MCOLN1 can specifically regulate autophagy
Activation of MCOLN1 can specifically regulate autophagyOn this basis, the researchers demonstrated that the influx of zinc from extracellular fluid can prevent autophagy through the same mechanism as lysosomal zinc, confirming the basic function of zinc as a participant in membrane trafficking.
Consistent with the in vitro results , administration of ML-SA5 in Patu 8988 t xenograft mice can effectively inhibit tumor growth and improve survival.
Administration of ML-SA5 in Patu 8988 t xenograft mice can effectively inhibit tumor growth and improve survival.
Original source:
Original source:Jiansong Qi et al.
Jiansong Qi et al.
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