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Autoimmun Rev: Factors associated with abnormal fertility in women with systemic lupus erythematosus

 Last Update: 2022-01-21
 Source: Internet
 Author: User

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Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that mainly affects adult women of reproductive age
.

In these patients, fertility is an area of concern because of disease-related factors (such as higher disease activity, lupus flares, or disease-related impairment), the psychosocial impact of chronic disease, and drug exposure that may damage the gonads function

Immune gonadal function may be impaired by disease-related factors (such as higher disease activity, lupus flares, or disease-related impairment), psychosocial effects of chronic disease, and drug exposure

RESULTS: Of the 789 abstracts reviewed, we included 46 studies, including 1 SLR study, 16 cross-sectional studies, 18 cohort studies, 10 observational studies, and 1 case series study involving 4704 patients Patients (mean age 31.
5±3.
7 years, disease duration 83.
27±38.
3 months)
.

The definition of premature ovarian failure (POF) used in the study varied depending on the number of months of amenorrhea and the age at onset of amenorrhea

Cyclophosphamide exposure (CYC) and its cumulative dose affect gonadal function in women with SLE, resulting in amenorrhea and POF

The strongest evidence regarding fertility-related factors in SLE women of reproductive age remains CYC therapy, and its cumulative dose

Factors associated with fertility abnormalities in women with systemic lupus erythematosus: a systematic review and meta-analysis.

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