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Severe infections caused by viruses, such as HIV or neocooptovirus, can quickly "paralyze" immune cell T cells, and improving the activity of T-cells in response to the mechanisms could help improve antiviral and cancer therapies, according to a new Australian study.
T cells are important immune cells, and in severe viral infections or cancers, their immune function may be impaired by what is known as T-cell depletion.
because T-cells are an important tool in some therapies such as anti-cancer immunotherapy, it is important to study the mechanism of T-cell depletion to improve related therapies.
in a new paper published in the British journal Nature Immunology, researchers at the University of Melbourne in Australia say they have found that severe viral infections can quickly "paralyze" T-cells, unlike in the past, when T-cell depletion was considered a slow process.
in mice showed that in weaker viral infections, T cells remained largely functional, but in severe viral infections, they could run out within a few days.
researchers say that if T-cells are adjusted early in a serious viral infection or cancer to increase their activity, they will help prevent T-cell depletion, which may improve some existing antiviral and cancer therapies. Axel Kallis, a professor at the University of Melbourne and author of the
paper, told Xinhua that further animal trials are needed to gradually push the method into clinical use because of the risk of serious side effects.
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