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Article source: Medical Rubik's Cube Info
Author: Shi Bei
On October 11, AstraZeneca announced that the long-acting antibody (LAAB) cocktail therapy AZD7442 has achieved positive and high-level results in the Phase III TACKLE trial for the treatment of COVID-19
AZD7442 is a combination of two long-acting antibodies, tixagevimab and cilgavimab
TACKLE is a phase III randomized, double-blind, placebo-controlled, multi-center trial designed to evaluate the safety and effectiveness of a single intramuscular injection of 600 mg AZD7442 compared with placebo in the outpatient treatment of COVID-19
The trial reached the primary endpoint.
In a pre-specified analysis of subjects who received treatment within 5 days of the onset of symptoms, AZD7442 reduced the risk of progression to severe COVID-19 or death (for any reason) by 67% compared with placebo.
AstraZeneca said it will discuss the data with health authorities
Note: The original text has been deleted