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    Home > Biochemistry News > Biotechnology News > Assessing the invasive and metastatic potential of cancer cells from tissue sections

    Assessing the invasive and metastatic potential of cancer cells from tissue sections

    • Last Update: 2022-04-24
    • Source: Internet
    • Author: User
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    Figure: Droplet shape changes using a non-contact stirring technique using an alternating electric field (ac)



    Rac and Cdc42* are widely studied low molecular weight G proteins that regulate the ability of cancer cells to move, termed their motility and invasiveness


    Until now, the motility and invasive ability of cancer cells have only been assessed by a biochemical method called the Rac/Cdc42 pull-down assay


    Fortunately, a research team consisting of Prof.


    The researchers used a recently developed non-contact stirring technique that uses an alternating electric field to "stir" droplets at extremely high speeds


    Their assessment revealed many insights into cellular Rac/Cdc42 activity


    According to Associate Professor Masumi Tsuda, "When developing this technique, we initially found it difficult to suppress the staining background and detect specific signals


    Article title:

    Novel rapid immunohistochemistry using an alternating current electric field identifies Rac and Cdc42 activation in human colon cancer FFPE tissues

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