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Science and Technology Daily, Beijing, February 13 (Intern Reporter Zhang Jiaxin) Harvard University and Emory University researchers collaborated to create a completely autonomous "artificial fish" using human stem cell-derived cardiomyocytes
The heart has two functional regulatory features: mechanical electrical signaling and automatism, which the researchers transferred into an artificial zebrafish device
"Through the mechanical electrical signals of the heart between the two layers of muscle, we reconstructed a system that automatically cycles with every contraction, " the researchers said
The researchers also designed an autonomous pacing node, which acts like a pacemaker and controls the frequency and rhythm of spontaneous contractions
"Because of two internal pacing mechanisms, our fish live longer, move faster and swim more efficiently than before," said Sung Jin Park, first author of the study and a former postdoc in the Marine Disease Biophysics Group.
The "physical fitness" of this artificial fish will improve with its "age"
"Our ultimate goal is to build an artificial heart that can replace a deformed heart in a child," said senior author Kit Parker, a professor of applied physics at Harvard University
Editor-in-Chief
The "artificial fish" in this study was made from human stem cell-derived cardiomyocytes, which can be described as one of the results of human stem cell research