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Semaphore includes a group of molecules with similar structures, characterized by the presence of a Sema domain of about 500 amino acids , which is widely expressed in immune cells and plays a role in various immune responses .
The purpose of this article is to study the potential role of semaphores in the pathogenesis of rheumatoid arthritis (RA) .
The purpose of this article is to study the potential role of semaphores in the pathogenesis of rheumatoid arthritis (RA) .
Methods: Microarray experiments were performed on endothelial cells (EC) from RA circulating progenitor cells and control ECs on the Affymetrix GeneChip human exon 1.
0 ST array
method:
Results: Microarray analysis revealed in RA ECs first three classes and 4 differentially expressed class of signals and their receptors
.
The mRNA levels of semaphorin 4A (SEMA4A) , plexin D1 and neuropilin 1 in RA ECs were significantly increased by 1.
75 , 2.
Results: Results: Microarray analysis reveals the RA ECs of the 3 classes and 4 classes semaphorin receptor expression and their differences
in conclusion:
Conclusion: Conclusion:By RA the ECs found in gene expression profiles of three classes and 4 classes as a prime signal RA is a potential candidate biomarkers and therapeutic targets
.
Semaphores are confirmed to be overexpressed in RA EC , synovial blood vessels and serum, and are associated with inflammation and angiogenesis markers
By RA the ECs found in gene expression profiles of three classes and 4 classes as a prime signal RA is a potential candidate biomarkers and therapeutic targets
Source:
Source:Avouac J, Pezet S, Vandebeuque E, Orvain C, Gonzalez V, Marin G, Mouterde G, Daïen C, Allanore Y.
Semaphorins: From Angiogenesis to Inflammation in Rheumatoid Arthritis.
Arthritis Rheumatol.
Avouac J, Pezet S, Vandebeuque E, Orvain C, Gonzalez V, Marin G, Mouterde G, Daïen C, Allanore Y.
Semaphorins: From Angiogenesis to Inflammation in Rheumatoid Arthritis.
Arthritis Rheumatol.
2021 Sep;73(9):1579- 1588.
doi: 10.
1002/art.
41701.
Epub 2021 Aug 6.
PMID: 33605067.
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