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Observational studies have shown that obesity ( defined using body mass index [BMI] ) is associated with rheumatoid arthritis (RA) risk, but its causal role is unclear
.
In addition, the significant weight loss in Swedish obese subjects after bariatric surgery did not reduce the risk of RA .
Observational studies have shown that obesity ( defined using body mass index [BMI] ) is associated with rheumatoid arthritis (RA) risk, but its causal role is unclear
In a summary of data from the genome-wide association study ( GWAS ) of approximately 500,000 people in the UK Biobank , bioelectrical impedance is used to measure body fat mass, body fat-free mass (muscles and internal organs), body fat percentage and limbs Lean body mass (mainly skeletal muscle)
In RA patient data GWAS analysis of 14,361 were RA patients (in line with 1987 American College of Rheumatology classification criteria or by a rheumatologist diagnosis) and 43,923 were assessed healthy controls (8)
In GWAS , the F statistic varies from 55 to 97 , indicating that the strength of the device is good (usually considered F>10 )
.
Each increase in body fat mass and body fat percentage is causally linked to a higher risk of RA (body fat mass, odds ratio [OR] 1.
41 [95% confidence interval (95% CI) 1.
In GWAS , the F statistic varies from 55 to 97 , indicating that the strength of the device is good (usually considered F>10 )
Conclusion: Conclusion: The gene prediction body fat measurements show that fat weight and RA there is a significant causal relationship between risk, but lean body mass and RA no causal link
Source:
Zhao SS, Maglio C, Hughes DM, Cook JP.
Body Fat Composition and Risk of Rheumatoid Arthritis: Mendelian Randomization Study.
Arthritis Rheumatol.
2021 Oct;73(10):1943-1944.
Zhao SS, Maglio C, Hughes DM, Cook JP.
Body Fat Composition and Risk of Rheumatoid Arthritis: Mendelian Randomization Study.
Arthritis Rheumatol.
2021 Oct;73(10):1943-1944.
doi: 10.
1002/art.
41766.
Epub 2021 Aug 24.
PMID: 33844473.
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