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Arthritis Rheumatol: Extramucosal formation in rheumatoid arthritis and prognostic value of secreted antibodies

 Last Update: 2022-01-21
 Source: Internet
 Author: User

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sulfasalazine rheumatoid arthritis

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Background: The mechanism of rheumatoid arthritis (RA) pathogenesis induction is unclear

Recent studies have shown that mucosal surfaces play an important role in the early development of RA, especially in ACPA-positive disease

The production of mucosal antibodies mainly involves the extracellular transport of immunoglobulin (Ig) A through the polyIg receptor (pIgR) located on the basolateral surface of epithelial cells

Methods: Three groups of patients were studied: (1) ACPA-positive patients with musculoskeletal pain but not arthritis; (2) patients with recent onset rheumatoid arthritis (RA); (3) previous rheumatoid arthritis ( RA) patients

Results: The serum levels of TsigA and TSIgM in early RA patients and high-risk RA patients were higher than those in healthy controls (P<0.

The serum levels of TsigA and TSIgM in patients with early RA and high-risk RA were higher than those in healthy controls.

Circulating secretory immunoglobulins were elevated both before and during the onset of RA

Extramucosal formation and prognostic value of secretory antibodies in rheumatoid

arthritis

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