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On May 20, Arnold Pharma announced that it had submitted a clinical trial application (IND) for its original innovative drug oral PD-L1 inhibitor AN4005 to the US FDA.
AN4005 can effectively induce and stabilize the formation and dimerization of PD-L1 dimers, thereby effectively destroying the interaction between PD-1/PD-L1 proteins.
Compared with monoclonal antibodies, small molecule PD-(L)1 inhibitors are expected to bring greater benefits.