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The mice are friendly
Have you ever met someone you like right away, or at other times, someone you don’t know why but you know right away that you don’t want to be friends with him?
The famous writer Malcolm Gladwell studied this phenomenon in his best-selling book The Blink
.
In his book, he pointed out that the "unconscious" part of the brain allows us to process information spontaneously, for example, when we first meet someone, interview someone for a job, or make quick decisions under pressure.
Now, a new study from the University of Maryland School of Medicine (UMSOM) suggests that there may be a biological basis behind this transient compatibility response
.
A team of researchers discovered that an enzyme mutation was found in the part of the brain that regulates emotions and motivation, which seems to control which mice want to socially interact with other mice—mice with similar genes prefer each other
UMSOM researchers, led by Dr.
Michy Kelly, associate professor of anatomy and neurobiology, said their findings may indicate that similar factors can also influence people's social choices
.
Understanding what drives these social preferences may help us better understand what is wrong with social withdrawal-related diseases, such as schizophrenia or autism, so that we can develop better treatments
The research was published in the journal Molecular Psychiatry on July 28
.
"We think this is just the first of many compatible biomarkers in the brain that may control social preferences," said Dr.
Kelly
.
"Imagine the possibility of truly understanding the factors behind human compatibility
Dr.
Kelly said that over the years, a series of unlikely events and situations finally reached the culmination of this research project
.
When she was working at a pharmaceutical company, a team of bone researchers asked Dr.
Kelly to describe the behavior of one of their mutant mice lacking the PDE11 protein
.
She observed that these mice without PDE11 withdrew from social activities, so she knew that PDE11 must exist in the brain
Later, as a faculty member at the University of South Carolina, she continued to study the social behavior of mutant mice, that is, their social response to smells
.
In the laboratory, the researchers removed wooden beads full of pungent air pheromones from one group of mice and placed them in a closed environment with another group of mice
A student working in the laboratory casually said that he noticed that children with autism prefer to interact with people with autism
.
Therefore, Dr.
"So, what determines the mouse's preference for friends?" Kelly said, "We ruled out smell and body movements as influencing factors, but we still have some other ideas to test
.
"
"This very important discovery is just the beginning.
In the future, there is hope to open up exciting new avenues for biological or social treatment of diseases such as schizophrenia or age-related cognitive decline.
Severe social avoidance and isolation may reduce one.
People’s quality of life
.
"
Original search:
DOI 10.
1038 / s41380-021-01237-4
