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ARD: The anti-fibrotic factor KLF4 is inhibited by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts

 Last Update: 2022-02-17
 Source: Internet
 Author: User

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Results: The study revealed distinct differentially expressed and methylated genes, including several transcription factors involved in stem cell differentiation and developmental programs ( KLF4 , KLF4 , , TBX5 , TBX5 , , TFAP2A , TFAP2A and HOXB3 , HOXB3 , , HOXB8 , HOXB8 , etc.

Source:

Malaab M, Renaud L, Takamura N , et al .

Malaab M, Renaud L, Takamura N , et al .
Antifibrotic factor KLF4 is repressed by the miR-10/TFAP2A/TBX5 axis in dermal fibroblasts: insights from twins discordant for systemic sclerosis.
, et al Annals of the Rheumatic DiseasesAnnals of the Rheumatic Diseases2022; 81: 268-277.
81:

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