ARD: A case series of SARS-CoV-2 booster doses for patients with autoimmune diseases

A weakened humoral response to SARS-CoV-2 vaccine
has been observed in some patients with autoimmune diseases .

Despite vaccination, immunosuppression still increased infection COVID-19 risk

A weakened humoral response to SARS-CoV-2 vaccine

Using prospective cohort, the researchers included in the 2021 Nian 4 Yue 10 to 6 Yue 11 between the date the report was inoculated a SARS-CoV-2 mRNA patients with autoimmune or adenoviral vector vaccine booster shot of

Repeated detection of anti spike antibodies after the booster dose is in the median of 30 days (the IQR 27 - 36) conducted

in conclusion:

Conclusion: Conclusion:

The findings of the study that the booster dose of SARS-CoV-2 vaccine enhanced the humoral response were similar to those of immunosuppressed solid organ transplant recipients ; the study participants showed a more pronounced humoral response enhancement, which may reflect the baseline immunity of patients with autoimmune diseases Disorders and the impact of immunosuppressive therapy before and after vaccination
.

The findings of the study that the booster dose of SARS-CoV-2 vaccine enhanced the humoral response were similar to those of immunosuppressed solid organ transplant recipients ; the study participants showed a more pronounced humoral response enhancement, which may reflect the baseline immunity of patients with autoimmune diseases Disorders and the impact of immunosuppressive therapy before and after vaccination
.

 

Source:

Source: Source:

Connolly CM, Teles M, Frey S, Boyarsky BJ, Alejo JL, Werbel WA, Albayda J, Christopher-Stine L, Garonzik-Wang J, Segev DL, Paik JJ.

Connolly CM, Teles M, Frey S, Boyarsky BJ, Alejo JL, Werbel WA, Albayda J, Christopher-Stine L, Garonzik-Wang J, Segev DL, Paik JJ.
Booster-dose SARS-CoV-2 vaccination in patients with autoimmune disease: a case series.
Ann Rheum Dis.
2021 Sep 7:annrheumdis-2021-221206.
doi: 10.
1136/annrheumdis-2021-221206.
Epub ahead of print.
PMID: 34493492.
Connolly CM, Teles M, Frey S, Boyarsky BJ , Alejo JL, Werbel WA, Albayda J, Christopher-Stine L, Garonzik-Wang J, Segev DL, Paik JJ.
Booster-dose SARS-CoV-2 vaccination in patients with autoimmune disease: a case series.
Ann Rheum Dis.
2021 Sep 7:annrheumdis-2021-221206.
doi: 10.
1136/annrheumdis-2021-221206.
Epub ahead of print.
PMID: 34493492.
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