Arbutin extract

Arbutin, also known as arbutin, is a white needle like crystal or powder Extracted from the leaves of bear fruit, it can accelerate the decomposition and excretion of melanin, so as to reduce the deposition of skin pigment, remove color spots and freckles, as well as the effect of sterilization and anti-inflammatory It is mainly used for the preparation of advanced cosmetics English Name: arbutin chemical name: p-hydroxybenzene-β-d-glucopyranoside alias: arbutin, arbutin, arbutin, arbutin, arbutine, ursin, uresol, arbutus extract molecular formula: c12h16o7 molecular weight: 272.25 CAS No.: 497-76-7 Physical and chemical indexes: appearance: white needle crystal or powder; content: ≥ 99.5% (HPLC); melting point: 197-200 (± 0.5) ℃; pH value: 6.0-6.8; heavy metal: ≥ 10ppm; hydroquinone content: ≥ 10ppm; specific rotation: = - 64.00 ± 1.00; infrared characteristic peak: 1515cm-1 1220cm-1 1050 ± (5-8) cm-1 Arbutin is a natural active substance derived from green plants It integrates "green plants, safety and reliability" and "efficient decolorization" into one skin decolorization component It can quickly penetrate into the skin, effectively inhibit the activity of tyrosinase in the skin and block the formation of melanin without affecting the cell proliferation concentration It can directly inhibit the activity of tyrosinase in the skin by itself and caseinase In combination, it can accelerate the decomposition and excretion of melanin, so as to reduce the deposition of skin pigment, remove the color spots and freckles, and has no toxic, irritant, sensitizing and other side effects on melanocytes, as well as bactericidal and anti-inflammatory effects It is the most popular safe and effective whitening material, and also the ideal skin whitening and freckle removing agent in the 21st century Main use: used in advanced cosmetics, can be formulated into skin cream, freckle cream, advanced pearl cream, etc., which can not only beauty skin care, but also anti-inflammatory, anti irritant Raw materials of scalding wound medicine: arbutin is the main component of new scalding wound medicine, characterized by rapid pain relief, strong anti-inflammatory force, rapid elimination of redness and swelling, fast healing and no scars Dosage form: spray or smear Intestinal anti-inflammatory materials: good bactericidal and anti-inflammatory effect, no toxic side effects In fact, the main effect of arbutin is skin lightening, which makes the skin look young and beautiful The use of arbutin in European and American countries is the use of this function With the expiration of more and more patents, arbutin, which was only used in high-grade cosmetics in the past, is becoming more and more popular Before we introduce ursolic acid, we introduce a substance: hydroquinone It can interfere with the formation of melanin to achieve whitening effect, but because of its irritancy, it will cause irritative dermatitis and pigment precipitation, which has been listed as prohibited cosmetics in many countries Arbutin introduces a glucose molecule into the molecule, reduces the stimulation effect, has the ability to interfere with melanocytes, desalinate the formed melanin, has good sun protection ability, strong spot lightening effect, and is used for the treatment of chloasma, freckle and other pigments, with good curative effect The limit of using in skin care products is 7% Arbutin is mainly extracted from the leaves of bear berry, and it can also be found in some fruits and other plants, such as Western pears, small mountain pears and Saxifraga (currently, arbutin is chemically synthesized) It has the effect of making the skin bright, can quickly penetrate into the skin without affecting the skin cells, combine with the tyrosinase which causes melanin production, can effectively block the activity of tyrosinase and the production of melanin, and accelerate the decomposition and elimination of melanin In addition, arbutin can protect skin from free radicals and has good hydrophilicity Therefore, arbutin is often added to the whitening products on the market, especially in Asian countries (Senior Tang's household whitening ingredient), which is one of the most popular whitening ingredients in recent years Arbutin can be divided into α type and β type according to its structure, both of which have the effect of inhibiting tyraminase to achieve whitening At present, β type is the most widely used one, which has been studied in detail It is said that 1 / 9 concentration of α type added to β type can inhibit the production of tyraminase and achieve whitening effect, but detailed toxicology research has not been seen Many care products added with α - arbutin all claim that they have a whitening effect ten times higher than traditional arbutin, but the actual effect has not been confirmed by clear data and experimental reports, but the whitening effect is still positive Many people are particularly afraid of the photosensitivity of arbutin In fact, they don't need to worry about it Experiments show that only arbutin with a concentration of more than 7% is likely to be sensitive to light, so 7% is a safe critical point The biggest feature of arbutin is that it can penetrate the basement layer for deep light spots For chloasma, blackspot, sunburn, and pigmentation left by drug allergy It has a strong therapeutic effect, but if the concentration is too low, the persistence of the effect will be weakened Therefore, 5% concentration is the safest and most efficient concentration for freckle lightening 5% concentration is faster than vitamine C in freckle lightening, and the lasting stability of freckle lightening will not have an irritant effect on the skin D-arbutin d-arbutin is one of the derivatives of arbutin, known as d-arbutin, which can effectively inhibit the effect of tyraminase in skin tissue According to the research, its effect is even 10 times that of hydroquinone, 350 times that of common arbutin In animal skin tests, the d-arbutin can whiten skin quickly and effectively, but the effect can be maintained for nearly 8 weeks after discontinuation of use In the clinical research of human body, local use of d-arbutin for 12 weeks can get obvious skin desalination effect, and it has a good improvement effect on the sun active insolation spots and dark skin color For the clinical research of d-arbutin, it is further pointed out that in the past, many kinds of tyrosinase inhibitors were used to alleviate the skin lesions caused by melanin accumulation D-arbutin made by QSAR (quantitative structure activity relationships) technology is a very effective component of tyrosinase inhibition, which has a significant blocking effect on skin melanin formation According to the test results of human skin melanocytes, the safe concentration of d-arbutin can be more than 4 times of hydroquinone when 95% of the cells survive, which indicates that the toxicity of d-arbutin to melanocytes is much safer than hydroquinone Furthermore, experiments on human skin keratinocytes (the main cells in the epidermis) and fibroblasts (the dermis) indicate that d-arbutin is still much less toxic to cells than hydroquinone What we need to make clear is that compared with hydroquinone, d-arbutin can achieve better effect than Hydroquinone at lower concentration When d-arbutin is stopped, the tyraminase function and melanin content in the skin will slowly recover, which means that d-arbutin will not cause the toxicity of melanocytes, and it can make melanocytes still have normal physiological mechanism In an 8-week clinical study, local use of d-arbutin can achieve gradual but significant skin whitening effect Another clinical study also pointed out that the appropriate concentration of d-arbutin solution can achieve good clinical effect within 3 weeks Moreover, according to the experiment, the effect of d-arbutin on melanin is 10 times that of hydroquinone, 150 times that of kojic acid, 350 times that of β - arbutin, and 38.5 times that of α - arbutin