Application of Siraitia grosvenorii extract

Siraitia grosvenorii is the fruit of Cucurbitaceae, a perennial herb vine, with a diameter of 4-6cm, spherical shape and luster It is known as a good medicine and good fruit It grows mostly in Guilin, Guangxi, China It is popular at home and abroad on the Internet Siraitia grosvenorii (Swingle) C Jeffrey is a famous Chinese herbal medicine, which belongs to the genus Siraitia of Cucurbitaceae Its main active ingredient is terpenoid saponins, which can also be used as non-toxic and harmless food additives It has a very important research value for the development of food industry and pharmaceutical industry A systematic study of Siraitia grosvenorii was carried out, involving the fruits, seed oil, flowers, leaves, tubers, etc it was found that the main medicinal active ingredients of Siraitia grosvenorii are glucosides, tannins, flavonoids, etc the new functions of Siraitia grosvenorii mainly include liver protection, bacteriostasis, antioxidation, blood lipid reduction, hypoglycemia, fatigue resistance, hypoxia resistance, high temperature resistance, immune enhancement and free radical elimination, etc It was found that there were many fatty acids, essential amino acids, flavonoids and a large number of triterpenoid glycosides in the extract of Siraitia grosvenorii At present, the research and utilization of Siraitia grosvenorii mainly focus on Siraitia grosvenorii, one of the extracts of Siraitia grosvenorii Siraiti grosvenorii is the main component of triterpenoids in Siraitia grosvenorii It is a kind of non sugar substance with strong sweet taste, and its sweetness is about 300 times that of the same amount of sucrose Modern pharmacology research has proved that Mogroside also has many biological activities, such as regulating blood glucose balance, fat metabolism, antioxidation and improving immunity, so Mogroside has great application prospects in food additives, functional food and dual-purpose Chinese medicine The research on the yellow pigment of Siraitia grosvenorii is still in a blank state, and it is found that the yellow pigment of Siraitia grosvenorii is a water-soluble pigment; the yellow pigment of Siraitia grosvenorii has good heat and light stability, strong resistance to reduction and weak resistance to oxidation; the yellow pigment of Siraitia grosvenorii has good stability to acid and alkali, so it has a wide range of application; except for Fe2+ In addition, the influence of other metal ions on the yellow pigment of Siraitia grosvenorii is relatively small; the influence of food additives on the yellow pigment of Siraitia grosvenorii is relatively small, and the pigment property is relatively stable [structure] structure of the main component of the extract of Siraitia grosvenorii: [application] [2] the medicinal history of Siraitia grosvenorii in China can be traced back to 300 years ago, which was considered by traditional Chinese medicine to have the effects of moistening the lungs and relieving cough, cooling blood and smoothing the intestines It is used to treat dry cough of lung fire, aphasia of pharyngeal pain, dry constipation of intestines, etc Modern pharmacology research has found that the main component of Siraitia grosvenorii extract is Siraitia grosvenorii glycoside, which has physiological activities such as hypoglycemia, antioxidation, liver protection, lipid-lowering and weight-loss, moistening intestines, defecation and anti-inflammatory 1 The hypoglycemic effect of Siraitia grosvenorii glycosides is extremely low in sweetness, but it will not cause the blood glucose to rise after eating This characteristic has attracted great attention of researchers The results showed that there was little difference in blood glucose content before and after administration, which indicated that the phenomenon of glucosinolates transforming into glucose was not obvious 2 Antioxidant free radicals are free in vivo, and the lipid peroxidation induced by them is closely related to the occurrence of many diseases In recent years, it has been found that Mogroside has the functions of scavenging free radicals and anti lipid peroxidation The anti superoxide anion kit method, colorimetry and d-deoxyribose method were used to analyze the effects of Mogroside on free radical scavenging and anti lipid peroxidation The results showed that Mogroside could inhibit lipid peroxidation of liver tissue in rats, and had protective effects on liver tissue peroxidation induced by Fe2 + and H2O2, indicating that Mogroside could effectively scavenge free radical 3 The protective effect of Mogroside on liver was studied in rats and mice The mice were administrated with rhamnoside once a day for 7 days, and 0.08% CCl4 was injected intraperitoneally in the gavage group and the model group one hour after the last gavage 12 hours after the establishment of the model, the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were measured and the pathological changes of the liver tissue were observed CCl4 was used to model rats for eight weeks to form chronic liver injury model The effects of rhG on serum ALT, AST, ha, P Ⅲ NP, Hyp, SOD, GSH PX and MDA were observed The results showed that Mogroside could reduce the activities of ALT and AST in serum of mice with acute liver injury, and obviously reduce the degree of pathological changes of liver tissue In CCl4 induced chronic liver injury, Mogroside can reduce the activity of ALT and AST in serum, the content of HA, P Ⅲ NP and Hyp, the activity of SOD and GSH PX in liver tissue, and the content of MDA in liver tissue It is suggested that Mogroside has protective effect on acute liver injury induced by CCl4 in mice, has preventive and therapeutic effect on chronic liver injury induced by CCl4 in rats, and has certain anti fibrosis effect 4 The sweetness of Mogroside is not sugar It can reduce the intake of glucose when used as sweetener As long as sugar intake is controlled, subcutaneous fat synthesis can be inhibited, lipid metabolism can be promoted, thus subcutaneous fat can be removed and weight loss can be achieved Rats were randomly divided into three groups: blank group, model control group and experimental group Rats in the experimental group were given rhamnoside by gavage, while rats in the blank group and model control group were given distilled water by gavage for 28 days During the feeding process, the body weight and food intake of the rats were recorded every week At the end of the experiment, the body length was measured, the body fat was cut and weighed, and the fat / body ratio was calculated At the same time, blood was collected, serum was separated, and the levels of serum triglyceride and total cholesterol were measured The results showed that compared with the control group, the experimental group lost 11.9% of body weight, 37.8% of LDL-C, 38.9% of triglyceride, 35.7% of body fat and 21.2% of total cholesterol 5 Other activities It has been reported that rhamnoside can inhibit the expression of CYP1A1 gene and the production of liver cancer In lipopolysaccharide activated mouse macrophage model, rhamnoside can significantly inhibit the protein and mRNA of inducible nitric oxide synthetase and cyclooxygenase-2 It can increase the percentage of acid α - naphthyl acetate positive lymphocytes in peripheral blood and the ratio of spleen specific rosette cells, improve the phagocytic function of cyclophosphamide immunosuppressive mice macrophages and the proliferation of T cells, and enhance the immunity [application] [2] [3] Siraitia grosvenorii glycoside, as a new low calorie, non sugar sweetener, has been widely used in food, additives and health products industry in recent years In the 1990s, the U.S Food and Drug Administration approved that rhG could be added to food as a sweetener In 1996, China also approved rhG as a substitute sugar for obese and diabetic patients, which could partially or completely replace sucrose and be used in health care products industry At present, the United Kingdom, South Korea, Japan, Singapore and other countries all allow rhamnoside as a food additive Among them, Japan is the largest importer of rhamnoside As a health product in Japan, rhamnoside can be made into diet food, hypoglycemic food, immunity enhancing food and anti allergy granules, etc.; as a sweetener, it can be processed into throat moistening sugar, functional drink, syrup and effervescent tablet, etc.; as an additive, rhamnoside can be added into the solution of pickled pickles, which can greatly reduce the use of rhamnoside The amount of salt, and pickled pickles crisp and refreshing, bright and attractive color In the UK, rhamnoside is often mixed with Pueraria extract to make a low sugar solid drink, which has a fresh smell after washing and dissolving, and has health care functions such as relieving fatigue, promoting digestion, reducing blood pressure, etc.; in addition, the soluble starch is mixed with rhamnoside and processed into square sugar, which can adjust the sweetness of brewing caffeine and reduce the heat intake In our country, the traditional Chinese medicine often uses Mogroside as a traditional Chinese medicine, which has the effect of moistening the lung and relieving cough, cooling blood, moistening the intestines and relieving constipation Since the 21st century, siraitin has also been widely used in China's food industry When it is added to starch soft candy, it can make candy with good taste, flavor and color; when it is added to biscuits, it can improve the structure and texture of biscuits, and make them chew smooth without dryness; when it is added to dairy products, it can promote the health of children, patients and sub-health people In recent years, the main physicochemical activities of Momordica grosvenin extracted from Momordica Grosvenor extract have been proved to be more physical and chemical activity With the physiological activity of Momordica Grosvenor, special foods such as anti diabetes, anti aging, anti constipation, lipid lowering, anti obesity and anti caries have been developed [preparation] [1] the extract of Siraitia grosvenorii is extracted by boiling, dried or mixed with sucrose to make granules, which are usually packaged after hot air drying The specific requirements are: 75~80 ℃, boiling for 110~130min The extract of Momordica Grosvenor extract, which is about 10 times thickening, can be obtained For example, 150kg of fresh Momordica grosvenvens, 120min is boiled at 80 degrees centigrade, and 10 times the content of 15kg extracted from Momordica Grosvenor can be concentrated Then granulator can be mixed with 15kg sucrose for granulation, and then dried by hot air drying, the granular extract of Momordica grosvenis can be obtained [main reference materials] [1] Ma Dianhong The growth promoting effect of Siraitia grosvenorii extract on piglets [J] Animal husbandry and veterinary science and technology information, 2017 (6): 21-21 [2] Li Yumeng, Zhang Zesheng, Qin Chengguang, et al Research progress on Extraction and activity of Siraitia grosvenorii [J] Food research and development, 2017 (8): 220-224 [3] Zhang Jing, Wu Youliang, Zhang Chanjuan, et al Research progress on pharmacological activity of Siraitia grosvenorii [J] China pharmaceutical, 2010, 19 (20): 84-86