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Microglia are key immune cells of the brain, which play a role in immune monitoring, regulate neuronal homeostasis in the physiological state, participate in a variety of central nervous system diseases under pathological conditions, and express disease-related genes
In the early stage, Adeno-associated virus type 2 and type 6 were used as vectors, and F4/80 and CD68 were used as promoters to specifically label microglia, but the efficiency of infected cells was low, there was partial off-target, and the problem of tissue immune response
On July 25, 2022, Luo Minlin Rui's team at the Beijing Institute of Life Sciences developed an efficient, convenient and integrated AAV virus vector tool for manipulating microglia, which greatly promoted the functional research of
1.
The researchers screened the capsid proteins AAV-cMG.
In order to achieve higher infection efficiency, they performed mutation screening on AAV-cMG.
Two AAV-cMG.
Figure 1: AAV-MG1.
2.
After AAV-MG1.
After AAV-MG1.
Further utilization of the AAV-MG1.
Figure 2: Gene-edited microglia function genes, causing dysfunction
In this paper, the AAV mutants AAV-MG1.
END
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