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Cyclophosphamide (Cyclophosphamide) is the most commonly used alkylating agent anti-tumor drug in clinical practice, which is widely used in the treatment of malignant lymphoma, breast cancer, ovarian cancer, cervical cancer, etc.
Microdialysis monitors the concentration of free drugs outside the cells of the tissue at the target site, so the concentration of the drug in the monitored tissue is more predictive than the quantitative results of traditional blood drug concentrations
Microdialysis sample collection and processing
1.
After the probe is rinsed with Ringer's solution, the linear microdialysis probe is immersed in a microdialysis reaction bottle containing 100 ml of Ringer's solution, and the drug (cin, 1.
2.
Rats are anesthetized by body weight (0.
3.
Take 20 μl of the dialysate sample with precision, add 10 μl of the internal standard solution, vortex for 10 s, and inject 2 μl
Figure 1 Typical spectra of CYCLOPHOSPHAMIDE and internal standard antipyrine in rat breast microdialysis by HPLC-MS/MS method
A: Blank dialysate; B: Blank dialysate + cyclophosphamide control (0.
Precision and accuracy of cyclophosphamide in microdialysis samples
The literature reports that cyclophosphamide is widely used in the combination therapy regimen of breast cancer and occupies a non-negligible position in the process of
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