Apple tree extract can relieve asthma symptoms

Recently, a study from Changgeng University of science and technology in Taiwan found that the flavonoids active substance phloretin (PT) from apple tree can help reduce the symptoms of severe respiratory hyperresponsiveness (AHR), respiratory inflammation and oxidative stress in induced asthma mice PT is a kind of substance existing in the fruit, leaves and bark of apple trees Previous studies have confirmed that PT has good effects in regulating glucose transporter, promoting tumor cell withering, increasing lipid metabolism and anti obesity In this study, rats were randomly divided into five groups, including normal group, ovalbumin induced asthma group, ova induced mice injected with 5 mg / kg, 10 mg / kg, 20 mg / kg dose Pt On days 14, 17, 20, and 23 of the study, the rats were exposed to 2% ova for 30 minutes One hour before the rats inhaled ova, the researchers had injected Pt into the abdominal cavity of some mice It is understood that after inhalation of atomized methacholine, the researchers tested the high responsiveness of the respiratory tract of rats through the index of breath interval (Penh), then evaluated the effect of respiratory function, and finally diagnosed whether the rats had asthma The results showed that after inhalation of 40 mg / ml of methacholine, the Penh index of rats in PT group was significantly lower than that in ova sensitive group Therefore, the researchers believe that PT can significantly reduce AHR in asthmatic mice In addition, the number of inflammatory cells and the expression of HO-1 were significantly decreased in the PT treated group Previous studies have confirmed that HO-1 can reduce the lung damage caused by oxidative stress The researchers pointed out that PT could significantly reduce the proliferation of goblet cells and eosinophil infiltration, and then reduce the respiratory hyperresponsiveness, inflammation and lung oxidation in ova sensitive mice At the same time, Pt alleviates pathological changes, inflammation and oxidative stress by inhibiting the production of Th2 cytokines in helper T cells (th) of asthmatic mice It was also found that PT could reduce inflammation and oxidative stress in LPS induced acute lung injury rats In general, Pt plays a role by inhibiting inflammatory response and alleviating oxidative stress, and has great potential in relieving asthma symptoms in the future.