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APL-1202 and tislelizumab combined treatment of new drug clinical research application approved by FDA

 Last Update: 2021-06-30
 Source: Internet
 Author: User

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On June 15, Yahong Pharmaceutical announced that the new drug clinical research application of APL-1202 and tislelizumab combined with neoadjuvant treatment of myometrial invasive bladder cancer (MIBC) was approved by the FDA.
This is an open, multi-center international clinical phase 1/2 study, the main objectives were to: assess the safety of combination therapy in patients with MIBC and MIBC as neoadjuvant therapy phase 2 clinical study of the efficacy of the recommended dose, and so on
.

APL-1202 is an oral reversible MetAP2 inhibitor developed by Yahong Pharmaceutical.
It has anti-angiogenesis, anti-tumor activity and regulation of tumor immune microenvironment.
It is currently carrying out first-line single-agent and second-line combined chemotherapy infusion therapy in China Phase 3 clinical trial in patients with non-muscular invasive bladder cancer (NMIBC)
.

Tilelizumab (Baizean) is a humanized lgG4 anti-PD-1 monoclonal antibody developed by BeiGene.

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