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The skin is the largest organ of the human body and protects the internal organs of the body from the many harmful effects of UV radiation from the sun by acting as a barrier
.
Photoaging is the result of prolonged exposure to the sun's ultraviolet radiation
It is important to note that many external factors have the ability to cause skin disorders
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Some of these diseases have different etiologies, and there are currently a variety of treatments for moderate to severe psoriasis, including phototherapy, systemic medications (eg, methotrexate and cyclosporine), oral treatments (eg, apilast) and topical treatment
An example of a naturally sourced substance with potential to treat skin diseases is propolis, a natural resin product made by honeybees using materials obtained from a variety of plant sources, which can be used to treat diseases caused by various factors such as UV rays or psoriasis.
skin disease
.
It is mixed with beeswax and enzymes secreted by bees through their salivary glands
diabetes
In terms of photoaging, there is evidence that flavonoids are involved in the regulation and repair of UV damage, such as DNA damage, inflammation, immunosuppression , cellular senescence and cell death due to telomere shortening
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The restoration of the homeostasis of the antioxidant system of flavonoids is related to the regulation of NF-κB, MAPK, STAT, JAK, NRF2 and the transcription of stress response genes such as GST, HO-1, and NQO-1
immunity
On the other hand, various flavonoids present in the chemical constituents of propolis have antipsoriatic activity; this activity is associated with the reduction of different cytokines and mediators, including tumor necrosis factor-alpha, nuclear factor-superoxide dismutase B , interleukin-1 superoxide dismutase, interleukin-17, interleukin-6, interleukin-22, interleukin-23, prostaglandin E_2 and cyclooxygenase; inhibit heat shock protein 90 subunits; and inducing their antioxidant activity to increase enzymatic and kappa activity, thereby reducing inflammation
.
In addition, the antiproliferative effects of flavonoids such as quercetin, baicalein, fisetin, kaempferol, and genistein may play an important role in alleviating psoriatic skin damage
As we have already mentioned, bee products and their derivatives, such as flavonoids, have been shown to have different health benefits, and processing and using pure bioactive compounds will make it easier to determine the specific dosage of each flavonoid, thereby Achieving a safe consumption level for people
.
Finally, some flavonoids have been shown to be effective in relieving other skin conditions, such as melasma and acne, and promoting the healing process, which is why bee products are a promising source of bioactive compounds to complement different skin conditions treatment, and even opened the door to studying other types of compounds, such as terpenoids, which are also found in bee products
Source: Rivera-Yañez CR, Ruiz-Hurtado PA, Mendoza-Ramos MI, Flavonoids Present in Propolis in the Battle against Photoaging and Psoriasis, Antioxidants (Basel) 2021 Dec 19;10(12)
Rivera-Yañez CR, Ruiz-Hurtado PA, Mendoza-Ramos MI, Flavonoids Present in Propolis in the Battle against Photoaging and Psoriasis, Antioxidants (Basel) 2021 Dec 19;10(12)leave a message here
