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Antibody diversity decreases with age

 Last Update: 2022-04-23
 Source: Internet
 Author: User

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The African killifish (Notobranchius furzeri) can be used to study the aging of the immune system

Source: Max Planck Institute for the Biology of Aging

Our immune systems work less and less as we age

The immune system must constantly respond to new attacks from pathogens and remember them in order to be protected from the next infection

"We wanted to know the antibody repertoire of the elderly," explained Dario Ricardo Valenzano, who led the study

Killifish are the shortest-lived vertebrates that can be preserved in the laboratory

less antibody diversity

The researchers were able to characterize all the antibodies produced by the killifish with a high degree of accuracy

"If different antibodies decrease with age, this could lead to a decrease in the ability to respond to infection

Extensive age-dependent loss of antibody diversity in naturally short-lived turquoise killifish

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