-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
The latest advances in intra-arterial intervention have greatly expanded the time window for vascular reconstruction treatment for patients with cerebral vascular occlusion
.
However, revascularization therapy is still only suitable for less than 20% of patients with ischemic stroke
Vascular stroke prevention
Because aspirin has antithrombotic activity, it is effective in secondary stroke prevention
.
However, the effect of aspirin on primary stroke prevention is neutral, although it may be beneficial for the prevention of atherosclerotic stroke in people at high cardiovascular risk (such as patients with large atherosclerosis)
Thrombotic cardiovascular Furthermore, there is no large-scale quantitative neurological imaging studies to investigate the effect of aspirin on the use of images and Results of pre-stroke
This multicenter study based on magnetic resonance imaging (MRI) included 5,700 consecutive acute first ischemic stroke patients from May 2011 to February 2014 who did not undergo intravenous thrombolysis or intravascular thrombectomy
.
Enhanced inverse probability weighting based on propensity score was performed to estimate the adjustment effect of aspirin use before stroke
The average age was 67 years (41% were women), and 15.
9% (n = 907) took aspirin before stroke
.
Pre-stroke use of aspirin (compared to no use) is significantly associated with a reduction in infarct volume (30% reduction), especially in strokes with aortic atherosclerosis (45% reduction)
In myocardial infarction stroke, pre-stroke use of aspirin is associated with a 50% reduction in the incidence of END (adjusted difference = -5.
4%, 95% confidence interval [CI] = -8.
9 to -1.
9)
.
Therefore, the use of aspirin before stroke is associated with a higher probability of a favorable outcome (3-month modified Rankin scale score <3), especially in aortic atherosclerotic stroke and cardioembolic stroke (adjusted difference = 7.
2%, 95%CI=1.
8 to 12.
5, adjusted difference=6.
4%, 95%CI=1.
7 to 11.
1, respectively)
.
Pre-stroke use of aspirin (as opposed to no use) is associated with an 85% reduction in the frequency of cerebral thrombosis-related susceptible vascular signs (SVS) in aortic atherosclerotic stroke (adjusted difference = -1.
4%, 95% CI = -2.
1 to- 0.
8, P <0.
001), which is related to a ~40% reduction in SVS volume, especially in myocardial infarction stroke (adjusted difference = -0.
16 cm3, 95% CI = -0.
29 to -0.
02, P = 0.
03)
.
In addition, there was no significant relationship between the use of aspirin before stroke and hemorrhagic transformation (adjusted difference = -1.
1%, p = 0.
09)
.
1%, p = 0.
09)
.
The significance of this study lies in the discovery that the use of aspirin before stroke may reduce infarct volume and/or END, possibly by reducing thrombus burden, and is related to improving the functional independence of patients with first ischemic aortic stroke without increasing hemorrhagic transition Risk
.
Original source:
Ryu W, Schellingerhout D, Hong K, et al.
Relation of Pre-Stroke Aspirin Use With Cerebral Infarct Volume and Functional Outcomes.
_Ann Neurol_.
Published online October 5, 2021:ana.
Relation of Pre-Stroke Aspirin Use With Cerebral Infarct Volume and Functional Outcomes.
_Ann Neurol_.
Leave a message here
