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Background: Many autoimmune diseases are caused by complex genetic and environmental factors and their interactions
.
Among them, the genetic factors of autoimmune diseases are revealed through various studies, such as genome-wide association studies
The gut microbiome, which refers to the community of microbes that inhabit our gut, has a major impact on our health through our immune and metabolic systems
Methods: Here, we performed whole-enterovirion sequencing analysis on 476 Japanese including patients with rheumatoid arthritis, patients with systemic lupus erythematosus, patients with multiple sclerosis, and healthy control subjects
.
RESULTS: Our case-control comparison of viral abundance revealed that in the gut of patients with autoimmune diseases, particularly those with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), as a major component of healthy enteroviruses One of the crAss-like phages was significantly reduced
.
In addition, Podoviridae were significantly reduced in the gut of SLE patients
Conclusion: Our data suggest that enteroviruses can affect our bodies directly or through bacteria
.
Our analysis elucidates a previously missing gut microbiota associated with autoimmunity and suggests novel candidate genes that contribute to the development of autoimmune disease
Our data suggest that enteroviruses can affect our bodies directly or through bacteria
Whole gut virome analysis of 476 Japanese revealed a link between phage and autoimmune disease.
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