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Ann Rheum Dis: Synovial fibroblasts targeting the IL-6-YAP-Snail signaling axis improve osteoarthritis

 Last Update: 2022-01-21
 Source: Internet
 Author: User

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Background: Rheumatoid arthritis (RA) is a common immune -mediated chronic inflammatory disease that can cause joint damage and deformity
.

Current treatments include antirheumatic drugs aimed at suppressing systemic immunity

Common immune -mediated chronic inflammatory diseases that can cause joint damage and deformity of immunity .

Methods: Immunohistochemistry and qRT-PCR were used to analyze the synovial tissue of RA patients and mice with antigen-induced arthritis (AIA)
.

Pdgfrα-CreER and Gdf5-Cr mice were targeted, hybridized with fluorescent reporters for cell tracking, and Yap-flox mice were subjected to conditional Yap ablation

RESULTS: Yap, its binding partner Snail and downstream target connective tissue growth factor were up-regulated in proliferative human RA and mouse AIA synovium, and Yap was detected in SF but not in macrophages
.

Lineage tracing revealed that Pdgfrα-expressing SFs expanded polyclonally during AIA, with expansion of Gdf5-lineage SF subsets primarily from the embryonic interarticular region

Conclusions: Our findings do not reveal the IL-6-YAP-Snail signaling axis of pathogenic SF in osteoarthritis

Our discovery and revelation of the IL-6-YAP-Snail signaling axis of pathogenic SF in osteoarthritis

Original source: Symons RA, Colella F, Collins FL, et al.

Targeting the IL-6-Yap-Snail signalling axis in synovial fibroblasts ameliorates inflammatory arthritis.

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