Ann Rheum Dis: Risk of venous thrombosis in knee, hip and hand osteoarthritis.

Osteoarthritis is the most common joint de-defying disease, with a prevalence rate of 46.3% among people over 40 years of age in China.
osteoarthritis is the main cause of limited mobility and joint replacement, which is an important risk factor for venous thrombosis (VTE).
a recent paper in Annals of The Rheumatic Diseases, the world's top journal in the field of rheumatology, analyzed the association between knee, hip and hand osteoarthritis and VTE risk, and explored the mediating role of joint replacement in this association.
researchers conducted three queue studies using data from the Health Improvement Network.
Each patient with osteoarthritis with knee joint (n=20,696), hip (n=10,411), or hand (n=6329) matched five patients with non-osteoarthritis based on age, sex, group time and body mass index.
the association between osteoarthritis and VTE (pulmonary embolism and deep vein thrombosis).
study found that 327 patients with knee osteoarthritis and 951 patients with non-osteoarthritis had VTE (2.7 vs 2.0 per 1,000 years) and a multivariable adjusted HR of 1.38 (95% CI of 1.23-1.56).
indirect effect of knee osteoarthritis on VTE through knee replacement (HR) was 1.07 (95% CI is 1.01-1.15), accounting for 24.8% of its total effect on VTE.
risk of VTE is higher in patients with hip osteoarthritis than in patients with non-osteoarthritis (3.3 vs. 1.8 per 1,000 years; HR s 1.83, 95% CI 1.56-2.13).
HR produced by the indirect effect of hip replacement was 1.14 (95% CI was 1.04-1.25), accounting for 28.1% of the total effect.
there was no significant difference in VTE risk between patients with hand osteoarthritis and patients with non-osteoarthritis (1.5 vs 1.6 per 1,000 years; HR=0.88,95% CI 0.67-1.16).
large-scale queue study provides evidence for the first time that knee or hip osteoarthritis is associated with an increased risk of VTE, rather than hand osteoarthritis.
and this association is mediated by knee or hip replacement.
.