Ann Neurol-transcranial direct current stimulation intervention may improve gait and balance

Standing and walking are two complex tasks that are essential for many activities of daily living
.

Although each task is performed under different biomechanical constraints, both tasks rely on a control system that needs to activate distributed cognitive and sensorimotor cortical networks

Transcranial direct current stimulation (tDCS) selectively modulates cortical excitability by sending low-level currents between electrodes on the scalp
.

The generated cortical electric field polarizes the neuron population and regulates the resting membrane potential

With advances in TDCS technology and electric field modeling, it is now possible to manage current through smaller gel electrode arrays , and to optimize specific aspects of the induced electric field in multiple cortical regions in one or more brain functional networks through montage design
.

Since both L-DLPFC and SM1 may contribute, this method may be particularly beneficial for enhancing dual-task standing and walking

management

Therefore, we aim to study the excitability of the optimized TDCS to promote L-DLPFC alone, the bilateral leg regions of SM1 alone, and the excitability of these two regions at the same time, and the dual tasks of standing and walking for the elderly Impact
.

We hypothesize that TDCS targeting these two regions (ie L-DLPFC+SM1) will reduce the cost of dual tasks, and this reduction will be greater than that of TDCS targeting these regions alone, and also greater than after the "active interference" stimulation program The reduction is greater

In this way, Junhong Zhou of Hinda and Arthur Marcus Institute for Aging Research and others explored the excitability of optimized TDCS to promote L-DLPFC alone, promote the bilateral leg regions of SM1 alone, and promote both regions at the same time.

The effect of excitability on the dual tasks of standing and walking in the elderly

Explore the effects of optimized TDCS on the excitability of L-DLPFC alone, the bilateral leg areas of SM1, and the excitability of these two areas at the same time, on the dual tasks of standing and walking in the elderly

They completed four separate study visits to 57 elderly people with no obvious disease, during which they received 20 minutes of transcranial direct current stimulation (tDCS), which was optimized to promote both the excitability of L-DLPFC and SM1 , Each area is carried out separately, or both areas are not carried out
.

Before and after stimulation, participants completed a dual-task paradigm, requiring them to stand and walk while performing or not performing a continuous reduced task

They found that the TDCS targeting both L-DLPFC and SM1, and the TDCS targeting L-DLPFC alone, reduced the cost of the dual tasks of standing and walking to a greater extent than targeting SM1 or fake TDCS alone (P<0.

02)

TDCS for L-DLPFC and SM1 at the same time, and TDCS for L-DLPFC alone, reduces the cost of the dual tasks of standing and walking to a greater extent than for SM1 or fake TDCS (P<0.
02) and at the same time for L-DLPFC TDCS with SM1, and TDCS for L-DLPFC alone, reduces the cost of the dual tasks of standing and walking to a greater extent than for SM1 or fake TDCS alone (P<0.
02)

These results indicate that in the elderly, the decline of dual tasks may be changeable, and implies that the excitability of L-DPFC is a modifiable component of the control system that enables dual tasks to stand and walk
.
tDCS can be used to improve the resilience of the elderly and the ability to walk and stand under challenging conditions, potentially improving daily functions
.

tDCS can be used to improve the resilience of the elderly and the ability to walk and stand under challenging conditions, potentially improving daily functions
.
tDCS can be used to improve the resilience of the elderly and the ability to walk and stand under challenging conditions, potentially improving daily functions
.

Original source:
Zhou J, Manor B, Yu W, Lo OY, Gouskova N, Salvador R, Katz R, Cornejo Thumm P, Brozgol M, Ruffini G, Pascual-Leone A, Lipsitz LA, Hausdorff JM.
Targeted tDCS mitigates dual- task costs to gait and balance in older adults.
Ann Neurol.
2021 Jul 2.
doi: 10.
1002/ana.
26156.
Epub ahead of print.
PMID: 34216034.

 

 

 

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