Ann Neurol: Retinal thickness predicts the risk of cognitive decline in Parkinson's disease.

In a recent study published in The Annals of Neurology, a authoritative journal in the field of neurology, researchers aim to analyze longitudinal changes in retinal thickness and their predictive value as biomarkers of the progression of idable Parkinson's disease (iPD) disease.
the study recruited patients with LBDs and conducted a three-year prospective assessment, including iPD (n-42), Louis-type dementia (DLB, n-4), E46K-SNCA mutant carriers (n-4) and controls (n-17).
all participants under the spectral retinal optically co-relevant fault scan and Montreal Cognitive Assessment (MoCA) were evaluated and received a patient's Parkinson's Disease Uniform Disease Assessment Scale (UPDRS) score.
researchers used a linear hybrid model to estimate the thickness reduction rate of the plex complex (GCIPL) and retinal nerve fiber layer (pRNFL) around the nipple, and used clinically significant thresholds to calculate the risk ratio to assess the association between baseline GCIPL and pRNFL thickness and subsequent cognitive and motor deterioration risk.
GCIPL thickness shrinks the most in the central concave area (1-3mm ring).
average annual atrophy rate was 0.63 m in patients with iPD and 0.23 m in the control group.
risk of cognitive decline in patients with lower GCIPL and pRNFL thickness after 3 years (RR is 3.49, 95% CI is 1.10-11.1, p is 0.03; RR is 3.28, 95% CI is 1.03-10.45, p is 0.045).
researchers found no significant association between retinal thickness and deterioration in motor ability.
, the results of this study provide evidence of the use of OCT to measure the thickness of GCIPL at the center's concave concave to monitor neurodegeneration and predict the risk of cognitive deterioration over time for iPD.
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