Ann Neurol: Cornell University's new discovery: cancer patients are susceptible to stroke, or due to blood hypercoagulability

It is estimated that 4-20% of patients with ischemic stroke have cancer, and the co-morbidity of these diseases is increasing
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This may be due to recent improvements in cancer treatment that have prolonged the survival of patients

Stroke diagnosis of pancreatic cancer

After standard diagnostic evaluation, approximately 50% of cancer-related strokes are classified as cryptogenic strokes
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In addition, the biological factors that contribute to the increased risk of stroke in cancer patients are still unclear, although recent studies have shown that hypercoagulability may play an important role

Although these two pathophysiological mechanisms are related to hypercoagulable state, their reproducibility and scalability may limit their clinical application

It can be increased by stroke itself and heart disease patients

They conducted a prospective cross-sectional study in two hospitals from 2016 to 2020
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And recruited 3 groups, each with 50 adult participants

The main outcome: pre-designated blood biomarkers and transcranial Doppler microemboli detection
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Blood biomarkers include coagulation markers (D-dimer and thrombin-antithrombin), platelet function (P-selectin) and endothelial integrity ( thrombomodulin , soluble intercellular adhesion molecule-1) [sICAM-1] and soluble vascular cell adhesion molecule-1 [sVCAM-1])

Thrombotic vascular

They found that the levels of biomarkers in all studies were different between the groups
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In the comparison between univariate groups, the levels of D-dimer, sICAM-1, sVCAM-1 and thrombomodulin in cancer plus stroke patients were higher than those of the two control groups;

In the comparison between univariate groups, the levels of D-dimer, sICAM-1, sVCAM-1 and thrombomodulin in patients with cancer plus stroke were higher than those of the two control groups; in the comparison between univariate groups, cancer plus stroke The levels of D-dimer, sICAM-1, sVCAM-1 and thrombomodulin in patients were higher than those of the two control groups;

The level of thrombin-antithrombin is higher than that of patients with only cancer; the level of P-selectin is higher than that of patients with only stroke
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In the multivariate analysis, the results found are similar

The significance of this study lies in the discovery that compared with matched controls, patients with cancer-related stroke have higher markers of blood coagulation, platelet and endothelial dysfunction, and more microemboli in the circulation
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It was found that compared with the matched control group, cancer-related stroke patients had higher markers of coagulation, platelet and endothelial dysfunction, and more microembolisms in the circulation
.

It was found that compared with the matched control group, cancer-related stroke patients had higher markers of coagulation, platelet and endothelial dysfunction, and more microembolisms in the circulation

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