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Ann Hematol: Management of Adverse Events in the Maintenance Treatment of Isazomib after Multiple Myeloma Transplantation

 Last Update: 2021-06-01
 Source: Internet
 Author: User

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The TOURMALINE-MM phase 3 study (NCT02181413) showed that after autologous stem cell transplantation (ASCT) in patients with multiple myeloma , maintenance therapy with ixazomib had an improved progression-free survival rate compared with placebo.

Stem cell management

The researchers randomly assigned patients at a ratio of 3:2 to receive ixazomib (n = 395) or placebo (n = 261), respectively, and received treatment on days 1, 8 and 15 of the 28-day cycle for a period of approximately 2 years or until disease/toxicity progresses.

The results showed that the incidence of grade ≥3 AEs in the ixazomib group (19%) was higher than that in the placebo group (5%), but the rate of discontinuation due to AEs was similar (7% vs.

In summary, the results of this study indicate that ixazomib is an effective and tolerable option for maintenance therapy after ASCT.

Original source:

Martin Kaiser, et al.

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