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Since the generation of the first laboratory-engineered viruses capable of replication in 1974, an evidence-based consensus has emerged that many changes introduced into the viral genome are likely to prove unstable if released into the environment
Non-circulating laboratory-modified virus vaccines are already in use today, for example as vaccines against rabies in wild animals or against polio in humans
The molecular tools necessary to create viral vaccines that maintain their ability to spread themselves have been around for some time
swine fever virus vaccine
In Spain, scientists are currently vaccinating pigs against African swine fever with a self-propagating virus, which has not been modified in the lab, as part of a closed experiment
"If self-transmitting vaccines, as it has been said, could be transformative in a wide range of agricultural, medical and conservation uses, developers and funders should focus on addressing needs within their own borders rather than continuing to recommend field testing in equatorial countries
