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Angiogenesis: a plasma biomarker that can predict the risk of bevacizumab-induced hypertension

 Last Update: 2021-06-01
 Source: Internet
 Author: User

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Hypertension is a common side effect of bevacizumab and other anti- angiogenic drugs .

Hypertension is bevacizumab and other anti- vascular generation drugs common side effects vessels

The study aims to identify plasma proteins related to the function of the vascular system to predict the risk of bevacizumab-induced hypertension.

Pretreated plasma samples from 398 patients treated with bevacizumab in two clinical trials (CALGB 80303 and 90401) were collected, and the levels of 17 proteins were detected by ELISA.

398 patients receiving bevacizumab

The average level of 17 proteins in the plasma of two test subjects

There were no differences in the levels of the five proteins in clinical trials and were included in further analysis.

Lower levels of Angiopoietin-2 , VEGF-A, and VCAM-1 are associated with an increased risk of grade 3 hypertension.

The levels of angiopoietin-2, VEGF-A and VCAM-1 in patients with ≥ grade 3 hypertension

The multivariate model suggested that Angiopoietin-2 (p=0.

The reduction in the levels of these three proteins or two of them at the same time indicates that the risk of bevacizumab-induced hypertension is further increased: OR 10.

Original source:

Quintanilha Julia CF,Liu Yingmiao,Etheridge Amy S et al.

org/10.
1007/s10456-021-09799-1">Plasma levels of angiopoietin-2, VEGF -A, and VCAM-1 as markers of bevacizumab-induced hypertension: CALGB 80303 and 90401 (Alliance)

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