Angewandte Chemie: New probe helps visualize detection of glioma markers

Recently, Huang Wei, a member of the Chinese Academy of Sciences, in collaboration with Li Lin, a professor at Nanjing University of Technology, and researchers from the National University of Singapore, designed and synthesized a new dual photon fluorescence probe, which will help to visually detect human-derived glioma markers (monoamine oxidase A, or MAO-A) in the futureThe results were published in the form of hot articles in Applied Chemistry in Germanyaccording to the introduction, the body's neurotransmitter metabolism needs to maintain a stable metabolic balance, if the function of monoamine oxidase abnormal, will be too much or too little metabolism of neurotransmitters, thereby destroying the metabolic balance of neurotransmitters in the organismTherefore, monoamine oxidase is closely related to central nervous system diseases and is an important biochemical marker in the study of central nervous system diseasesLi Lin,of the, said that based on the differences in their metabolic substrates, monoamine oxidase is divided into two subtypes (MAO-A and MAO-B), and THAT MAO-A and MAO-B are like twin brothers, with very similar structures and amino acid sequence similarity of more than 70%Their dysfunction is associated with different diseasesIn Parkinson's disease, MAO-B is used as a biochemical marker, while MAO-A is used as a colloidal markerHow to make the designed molecular probe sit more specific and sensitive to distinguish between the two precisely, thereby assisting the specific detection of two disease markers, glioma and Parkinson's disease, is a challenging and biological workin previous studies, the team has designed a MAO-B-specific dual photon fluorescence probe U1On the basis of the structure of U1, the team has designed a new MAO-A-specific dual photon fluorescent probe F1 to determine the activity of MAO-A in the detector by the fluorescence signal after the probe and MAO-A reaction, thus helping to achieve visual precision detection of the marker-MAO of human-derived gliomait is understood that the new MAO-A probe will provide a powerful research tool for the study of the correlation between glioma and Parkinson's disease, two distinct central nervous system diseases